Evidence map›Paper›PMID 38187749›Full record

ArticlebioRxiv : the preprint server for biology2024

Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane.

Aubrie M Stricker, M Shane Hutson, Andrea Page-McCaw

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Aubrie M StrickerDepartment of Cell and Developmental Biology, Center for Matrix Biology, Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-4922-2312
M Shane HutsonDepartment of Physics and Astronomy, Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Andrea Page-McCawDepartment of Cell and Developmental Biology, Center for Matrix Biology, Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-3193-5362
Vanderbilt University · US

Funding

Basement Membrane Homeostasis and RepairR01GM137595 · NIGMS · VANDERBILT UNIVERSITY · PI PAGE-MCCAW, ANDREA · 2020 to 2023
$1.4M
Basement membrane repair dynamics in the Drosophila midgutF31GM148021 · NIGMS · VANDERBILT UNIVERSITY · PI STRICKER, AUBRIE · 2022 to 2024
$91k
NIGMS NIH HHS F31 GM148021NIGMS NIH HHS R01 GM137595
6 · The paper itself

Abstract

Basement membranes are extracellular matrix sheets separating tissue layers and providing mechanical support, and Collagen IV (Col4) is their most abundant protein. Although basement membranes are repaired after damage, little is known about repair, including whether and how damage is detected, what cells repair the damage, and how repair is controlled to avoid fibrosis. Using the intestinal basement membrane of adult

Indexed as

Basement membraneCollagen IVDrosophilaenteroblastsintestinal stem cellsmatrixmidgutPiezorepairtensional stiffness

Identifiers

PMID38187749
PMCPMC10769369
OpenAlexW4390154759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.