Evidence map›Paper›PMID 38187732›Full record

ArticlebioRxiv : the preprint server for biology2023

Identification of arginine-vasopressin receptor 1a (Avpr1a/AVPR1A) as a novel candidate gene for chronic visceral pain.

Leena Kader, Adam Willits, Sebastian Meriano, Julie A Christianson, Jun-Ho La, Bin Feng, Brittany Knight, Gulum Kosova, Jennifer Deberry, Matthew Coates and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Leena KaderDepartment of Anesthesiology, Pain, and Perioperative Medicine, KU Medical Center, Kansas City, KS, United States.
Adam WillitsDepartment of Anesthesiology, Pain, and Perioperative Medicine, KU Medical Center, Kansas City, KS, United States.
Sebastian MerianoDepartment of Anesthesiology, Pain, and Perioperative Medicine, KU Medical Center, Kansas City, KS, United States.
Julie A ChristiansonDepartment of Cell Biology and Physiology, KU Medical Center, Kansas City, KS, United States.ORCID 0000-0003-4117-5192
Jun-Ho LaDepartment of Neurobiology, University of University of Texas Medical Branch, Galveston, TX.
Bin FengBiomedical Engineering Department, University of Connecticut, Storrs, CT.
Brittany KnightDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT, United States.
Gulum KosovaTenSixteen Bio, Suffolk, MA, United States.
Jennifer DeberryDepartment of Anesthesiology & Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Matthew CoatesDepartment of Medicine, Division of Gastroenterology & Hepatology, Penn State College of Medicine, Hershey, PA, United States.
Jeffrey HyamsDepartment of Gastroenterology, Connecticut Children's Medical Center, Hartford, CT.
Kyle BaumbauerDepartment of Anesthesiology, Pain, and Perioperative Medicine, KU Medical Center, Kansas City, KS, United States.ORCID 0000-0003-0437-9209
Erin E YoungDepartment of Anesthesiology, Pain, and Perioperative Medicine, KU Medical Center, Kansas City, KS, United States.
The University of Kansas Health System · USConnecticut Children's Medical Center · USPenn State Milton S. Hershey Medical Center · USThe University of Texas Medical Branch at Galveston · USUConn Health · USUniversity of Alabama at Birmingham · USUniversity of Connecticut · USUniversity of Kansas Medical Center · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

Chronic abdominal pain in the absence of ongoing disease is the hallmark of disorders of gut-brain interaction (DGBIs), including irritable bowel syndrome (IBS). While the etiology of DGBIs remains poorly understood, there is evidence that both genetic and environmental factors play a role. In this study, we report the identification and validation of

Indexed as

disorders of gut-brain interactionenteric nervous systemgeneticsirritable bowel syndromevisceral hypersensitivity

Identifiers

PMID38187732
PMCPMC10769202
OpenAlexW4390010669

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.