Evidence map›Paper›PMID 38187724›Full record

ArticlebioRxiv : the preprint server for biology2024

Reliability of task-based fMRI in the dorsal horn of the human spinal cord.

Alice Dabbagh, Ulrike Horn, Merve Kaptan, Toralf Mildner, Roland Müller, Jöran Lepsien, Nikolaus Weiskopf, Jonathan C W Brooks, Jürgen Finsterbusch, Falk Eippert

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Alice DabbaghMax Planck Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Ulrike HornMax Planck Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID 0000-0001-9119-0468
Merve KaptanMax Planck Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID 0000-0001-8187-4911
Toralf MildnerMethods & Development Group Nuclear Magnetic Resonance, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID 0000-0001-9163-1083
Roland MüllerMethods & Development Group Nuclear Magnetic Resonance, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Jöran LepsienMethods & Development Group Nuclear Magnetic Resonance, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Nikolaus WeiskopfDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID 0000-0001-5239-1881
Jonathan C W BrooksSchool of Psychology, University of East Anglia Wellcome Wolfson Brain Imaging Centre (UWWBIC), Norwich, United Kingdom.ORCID 0000-0003-3335-6209
Jürgen FinsterbuschDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Falk EippertMax Planck Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID 0000-0002-3986-1719
Max Planck Institute for Human Cognitive and Brain Sciences · DEUniversität Hamburg · DEUniversity of East Anglia · GBWellcome Centre for Human Neuroimaging · GB

Funding

Characterization of central pain mechanisms using simultaneous spinal cord-brain functional imagingR01NS109450 · NINDS · STANFORD UNIVERSITY · PI GLOVER, GARY H, MACKEY, SEAN C · 2018 to 2022
$2.9M
NINDS NIH HHS R01 NS109450
6 · The paper itself

Abstract

The application of functional magnetic resonance imaging (fMRI) to the human spinal cord is still a relatively small field of research and faces many challenges. Here we aimed to probe the limitations of task-based spinal fMRI at 3T by investigating the reliability of spinal cord blood oxygen level dependent (BOLD) responses to repeated nociceptive stimulation across two consecutive days in 40 healthy volunteers. We assessed the test-retest reliability of subjective ratings, autonomic responses, and spinal cord BOLD responses to short heat pain stimuli (1s duration) using the intraclass correlation coefficient (ICC). At the group level, we observed robust autonomic responses as well as spatially specific spinal cord BOLD responses at the expected location, but no spatial overlap in BOLD response patterns across days. While autonomic indicators of pain processing showed good-to-excellent reliability, both

Indexed as

fMRIheat painhumanreliabilityspatial specificityspinal cord

Identifiers

PMID38187724
PMCPMC10769329
OpenAlexW4390154651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.