Evidence map›Paper›PMID 38187717›Full record

ArticlebioRxiv : the preprint server for biology2023

Enzyme Fragment Complementation Driven by Nucleic Acid Hybridization.

Zihan Xu, Xiaoyu Zhang, Chandan Pal, Eriks Rozners, Brian P Callahan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Zihan XuDepartment of Chemistry, Binghamton University, The State University of New York, 4400 Vestal Parkway East Binghamton, New York, 13902, USA.
Xiaoyu ZhangDepartment of Chemistry, Binghamton University, The State University of New York, 4400 Vestal Parkway East Binghamton, New York, 13902, USA.
Chandan PalDepartment of Chemistry, Binghamton University, The State University of New York, 4400 Vestal Parkway East Binghamton, New York, 13902, USA.
Eriks RoznersDepartment of Chemistry, Binghamton University, The State University of New York, 4400 Vestal Parkway East Binghamton, New York, 13902, USA.
Brian P CallahanDepartment of Chemistry, Binghamton University, The State University of New York, 4400 Vestal Parkway East Binghamton, New York, 13902, USA.

Funding

Chemical Approaches to Control the Function of Regulatory RNAsR35GM130207 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI ERIKS ROZNERS · 2019 to 2026
$3.7M
Rapid SARS-CoV-2 Detection Using Amplicon Templated Reporter Enzyme AssemblyR03AI163907 · NIAID · STATE UNIVERSITY OF NY,BINGHAMTON · PI CALLAHAN, BRIAN PATRICK · 2021 to 2022
$157k
NIAID NIH HHS R03 AI163907NIGMS NIH HHS R35 GM130207
6 · The paper itself

Abstract

A modified protein fragment complementation assay has been designed and validated as a gain-of-signal biosensor for nucleic acid:nucleic acid interactions. The assay uses fragments of NanoBiT, the split luciferase reporter enzyme, that are esterified at their C-termini to steramers, sterol-modified oligodeoxynucleotides. The

Identifiers

PMID38187717
PMCPMC10769296

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.