Evidence map›Paper›PMID 38187710›Full record

ArticlebioRxiv : the preprint server for biology2023

Anp32e protects against accumulation of H2A.Z at Sox motif containing promoters during zebrafish gastrulation.

Fabian N Halblander, Fanju W Meng, Patrick J Murphy

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fabian N HalblanderDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester NY, 14642, USA.
Fanju W MengDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester NY, 14642, USA.
Patrick J MurphyDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester NY, 14642, USA.ORCID 0000-0002-0880-392X
University of Rochester Medical Center · US

Funding

Function of Chromatin Features in Cellular ProgrammingR35GM137833 · NIGMS · UNIVERSITY OF ROCHESTER · PI Patrick J. Murphy · 2020 to 2026
$2.8M
NIGMS NIH HHS R35 GM137833
6 · The paper itself

Abstract

Epigenetic regulation of chromatin states is crucial for proper gene expression programs and progression during development, but precise mechanisms by which epigenetic factors influence differentiation remain poorly understood. Here we find that the histone variant H2A.Z accumulates at Sox motif-containing promoters during zebrafish gastrulation while neighboring genes become transcriptionally active. These changes coincide with reduced expression of

Indexed as

Anp32echromatin accessibilityembryonic developmentH2A.Zneural crestSox

Identifiers

PMID38187710
PMCPMC10769258
OpenAlexW4389913966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.