Evidence map›Paper›PMID 38187690›Full record

ArticlebioRxiv : the preprint server for biology2024

Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and its Impact on Proteostasis.

Jeson J Li, Nan Xin, Chunxia Yang, Larissa A Tavizon, Ruth Hong, Jina Park, Travis I Moore, Rebecca George Tharyan, Adam Antebi, Hyun-Eui Kim

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jeson J Li
Nan Xin
Chunxia Yang
Larissa A Tavizon
Ruth Hong
Jina Park
Travis I Moore
Rebecca George Tharyan
Adam AntebiORCID 0000-0002-7241-3029
Hyun-Eui KimORCID 0000-0003-1495-1993
The University of Texas MD Anderson Cancer Center · USMax Planck Institute for Biology of Ageing · DERice University · USThe University of Texas Health Science Center at Houston · USUniversity of Cologne · DE

Funding

Mechanoregulation of the Leukocyte Specific Integrin LFA-1 by the Actin CytoskeletonK01HL143111 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOORE, TRAVIS I · 2018 to 2022
$856k
NHLBI NIH HHS K01 HL143111
6 · The paper itself

Abstract

Maintaining protein homeostasis is essential for cellular health. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response, activated by the perturbation of mitochondrial proteostasis, which ultimately results in the improvement of proteostasis in the cytosol. Here, we found that this signaling axis also influences the unfolded protein response of the endoplasmic reticulum (UPR

Identifiers

PMID38187690
PMCPMC10769184
OpenAlexW4386561847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.