Evidence map›Paper›PMID 38187686›Full record

ArticlebioRxiv : the preprint server for biology2023

HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2.

Venecia Valdez, Meisheng Ma, Bernardo Gouveia, Rui Zhang, Sabine Petry

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Venecia ValdezPrinceton University, Department of Molecular Biology, Princeton, New Jersey, United States.ORCID 0000-0002-5562-9151
Meisheng MaDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine (St. Louis, Missouri, United States).
Bernardo GouveiaPrinceton University, Department of Chemical and Biological Engineering, Princeton, New Jersey, United States.ORCID 0000-0003-2605-0973
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine (St. Louis, Missouri, United States).ORCID 0000-0003-3159-9565
Sabine PetryPrinceton University, Department of Molecular Biology, Princeton, New Jersey, United States.ORCID 0000-0002-8537-9763
Princeton University · USWashington University in St. Louis · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Role and Mechanisms of Microtubule Nucleation in Spindle AssemblyR01GM141100 · NIGMS · PRINCETON UNIVERSITY · PI PETRY, SABINE · 2022 to 2025
$2.0M
Structural and functional studies of axonemal microtubule inner proteins (MIPs)R01GM138854 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, RUI · 2020 to 2024
$2.0M
NIGMS NIH HHS R01 GM138854NIGMS NIH HHS R01 GM141100NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

In large vertebrate spindles, the majority of microtubules are formed via branching microtubule nucleation, whereby microtubules nucleate along the side of pre-existing microtubules. Hepatoma up-regulated protein (HURP) is a microtubule-associated protein that has been implicated in spindle assembly, but its mode of action is yet to be defined. In this study, we show that HURP is necessary for RanGTP-induced branching microtubule nucleation in

Identifiers

PMID38187686
PMCPMC10769297
OpenAlexW4389902263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.