Evidence map›Paper›PMID 38187675›Full record

ArticlebioRxiv : the preprint server for biology2023

Mapping the bioimaging marker of Alzheimer's disease based on pupillary light response-driven brain-wide fMRI in awake mice.

Xiaochen Liu, David Hike, Sangcheon Choi, Weitao Man, Chongzhao Ran, Xiaoqing Alice Zhou, Yuanyuan Jiang, Xin Yu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaochen Liu
David Hike
Sangcheon Choi
Weitao Man
Chongzhao Ran
Xiaoqing Alice Zhou
Yuanyuan Jiang
Xin Yu
Harvard University · US

Funding

Investigating the neurophysiological basis of circuit-specific laminar rs-fMRIRF1NS124778 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BISWAL, BHARAT BHUSAN, BROWN, EMERY N · 2022 to 2022
$2.1M
Develop a multi-modal cross-scale fMRI platform with laminar-specific cellular recordings through multi-channel tapered photonic crystal fiber arrayRF1NS113278 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XIN · 2019 to 2019
$2.0M
Upgrade of the Preclinical Horizontal 14T MagnetS10OD036211 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XIN · 2024 to 2024
$2.0M
Bridging the cellular and microvascular anatomy and functional dynamics: Upgrade the 14T horizontal MR for rodent and ex-vivo imagingS10MH124733 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R, YU, XIN · 2020 to 2020
$600k
NIH HHS S10 OD036211NIMH NIH HHS S10 MH124733NINDS NIH HHS RF1 NS113278NINDS NIH HHS RF1 NS124778
6 · The paper itself

Abstract

Pupil dynamics has emerged as a critical non-invasive indicator of brain state changes. In particular, pupillary-light-responses (PLR) in Alzheimer's disease (AD) patients may be used as biomarkers of brain degeneration. To characterize AD-specific PLR and its underlying neuromodulatory sources, we combined high-resolution awake mouse fMRI with real-time pupillometry to map brain-wide event-related correlation patterns based on illumination-driven pupil constriction (

Identifiers

PMID38187675
PMCPMC10769340
OpenAlexW4390042636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.