Evidence map›Paper›PMID 38187643›Full record

ArticlebioRxiv : the preprint server for biology2023

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery.

Qin Huang, Ken Y Chan, Shan Lou, Casey Keyes, Jason Wu, Nuria R Botticello-Romero, Qingxia Zheng, Jencilin Johnston, Allan Mills, Pamela P Brauer and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 1 institution in 3 countries.

Qin HuangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Ken Y ChanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Shan LouStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Casey KeyesStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Jason WuStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Nuria R Botticello-RomeroStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Qingxia ZhengStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Jencilin JohnstonStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Allan MillsStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Pamela P BrauerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Gabrielle ClouseStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Simon PacouretStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
John W HarveyStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Thomas BeddowStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Jenna K HurleyStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Isabelle G TobeyStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.ORCID 0000-0001-5428-3809
Megan PowellStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.
Albert T ChenStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.ORCID 0000-0002-5387-0208
Andrew J BarryStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.ORCID 0000-0002-4667-679X
Fatma-Elzahraa EidStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.ORCID 0000-0002-6822-9536
Yujia A ChanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.ORCID 0000-0002-0731-637X
Benjamin E DevermanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, USA.ORCID 0000-0002-6223-9303
Broad Institute · US

Funding

Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.UG3MH120096 · NIMH · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E, FISHELL, GORDON J · 2019 to 2021
$6.7M
Novel AAVs Engineered for Efficient and Noninvasive Cross-Species Gene Editing Throughout the Central Nervous SystemUH3NS111689 · NINDS · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E · 2021 to 2022
$2.7M
Novel AAVs engineered for efficient and noninvasive cross-species gene editing throughout the central nervous systemUG3NS111689 · NINDS · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E · 2018 to 2020
$2.5M
NIMH NIH HHS UG3 MH120096NINDS NIH HHS UG3 NS111689NINDS NIH HHS UH3 NS111689
6 · The paper itself

Abstract

Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an AAV capsid, BI-hTFR1, that binds human Transferrin Receptor (TfR1), a protein expressed on the blood-brain barrier (BBB). BI-hTFR1 was actively transported across a human brain endothelial cell layer and, relative to AAV9, provided 40-50 times greater reporter expression in the CNS of human

Identifiers

PMID38187643
PMCPMC10769326
OpenAlexW4390126824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.