Evidence map›Paper›PMID 38187635›Full record

ArticlebioRxiv : the preprint server for biology2023

Modulation of prion protein expression through cryptic splice site manipulation.

Juliana E Gentile, Taylor L Corridon, Meredith A Mortberg, Elston Neil D'Souza, Nicola Whiffin, Eric Vallabh Minikel, Sonia M Vallabh

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Juliana E GentileMcCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.
Taylor L CorridonMcCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.
Meredith A MortbergMcCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.
Elston Neil D'SouzaBig Data Institute and Centre for Human Genetics, University of Oxford, Oxford OX3 7LF, UK.
Nicola WhiffinBig Data Institute and Centre for Human Genetics, University of Oxford, Oxford OX3 7LF, UK.ORCID 0000-0003-1554-6594
Eric Vallabh MinikelMcCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0003-2206-1608
Sonia M VallabhMcCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0003-3824-2702
Broad Institute · USCentre for Human Genetics · GB

Funding

How Substrate Dosage Drives Prion Disease KineticsR01NS125255 · NINDS · BROAD INSTITUTE, INC. · PI Sonia Minikel Vallabh · 2022 to 2026
$2.7M
NINDS NIH HHS R01 NS125255Wellcome Trust
6 · The paper itself

Abstract

Lowering expression of prion protein (PrP) is a well-validated therapeutic strategy in prion disease, but additional modalities are urgently needed. In other diseases, small molecules have proven capable of modulating pre-mRNA splicing, sometimes by forcing inclusion of cryptic exons that reduce gene expression. Here, we characterize a cryptic exon located in human

Identifiers

PMID38187635
PMCPMC10769280
OpenAlexW4390011935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.