Evidence map›Paper›PMID 38187595›Full record

ArticlebioRxiv : the preprint server for biology2023

Chromosome fusion and programmed DNA elimination shape karyotypes of parasitic nematodes.

James R Simmons, Brandon Estrem, Maxim V Zagoskin, Ryan Oldridge, Sobhan Bahrami Zadegan, Jianbin Wang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

James R SimmonsDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, 37996, USA.
Brandon EstremDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, 37996, USA.
Maxim V ZagoskinDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, 37996, USA.
Ryan OldridgeDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, 37996, USA.
Sobhan Bahrami ZadeganUT-ORNL Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, Tennessee, 37996, USA.
Jianbin WangDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, 37996, USA.
University of Tennessee at Knoxville · US

Funding

Programmed DNA Elimination in Parasitic NematodesR01AI155588 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Jianbin Wang · 2020 to 2026
$3.0M
A genetic model for metazoan programmed DNA eliminationR01GM151551 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Jianbin Wang · 2023 to 2026
$1.2M
NIAID NIH HHS R01 AI155588NIGMS NIH HHS R01 GM151551
6 · The paper itself

Abstract

A growing list of metazoans undergo programmed DNA elimination (PDE), where a significant amount of DNA is selectively lost from the somatic genome during development. In some nematodes, PDE leads to the removal and remodeling of the ends of all germline chromosomes. In several species, PDE also generates internal breaks that lead to sequence loss and an increased number of somatic chromosomes. The biological significance of these karyotype changes associated with PDE and the origin and evolution of nematode PDE remain largely unknown. Here, we assembled the single germline chromosome of the horse parasite

Indexed as

centromerechromosome fusionDNA breakgenomekaryotypemeiosisnematodeParascarisprogrammed DNA eliminationsatellite DNA

Identifiers

PMID38187595
PMCPMC10769430
OpenAlexW4390154767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.