Evidence map›Paper›PMID 38187574›Full record

ArticlebioRxiv : the preprint server for biology2023

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

Hasan Alhaddad, Oscar E Ospina, Mariam Lotfy Khaled, Yuan Ren, Peter Forsyth, Yolanda Pina, Robert Macaulay, Vincent Law, Kenneth Y Tsai, W Douglas Cress and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Hasan AlhaddadDepartment of Metabolism and Physiology at the Moffitt Cancer Center, Tampa, Florida, USA.
Oscar E OspinaDepartment of Biostatistics and Bioinformatics at the Moffitt Cancer Center, Tampa, Florida, USA.
Mariam Lotfy KhaledDepartment of Metabolism and Physiology at the Moffitt Cancer Center, Tampa, Florida, USA.
Yuan RenDepartment of Metabolism and Physiology at the Moffitt Cancer Center, Tampa, Florida, USA.
Peter ForsythDepartment of Tumor Biology at the Moffitt Cancer Center, Tampa, Florida, USA.
Yolanda PinaDepartment of NeuroOncology at the Moffitt Cancer Center, Tampa, Florida, USA.
Robert MacaulayDepartment of Pathology at the Moffitt Cancer Center, Tampa, Florida, USA.
Vincent LawDepartment of Tumor Biology at the Moffitt Cancer Center, Tampa, Florida, USA.
Kenneth Y TsaiDepartment of Pathology at the Moffitt Cancer Center, Tampa, Florida, USA.
W Douglas CressDepartment of Molecular Oncology at the Moffitt Cancer Center, Tampa, Florida, USA.ORCID 0000-0002-9119-3658
Brooke FridleyDepartment of Biostatistics and Bioinformatics at the Moffitt Cancer Center, Tampa, Florida, USA.
Inna SmalleyDepartment of Metabolism and Physiology at the Moffitt Cancer Center, Tampa, Florida, USA.ORCID 0000-0002-6796-9145
Moffitt Cancer Center · USUniversity of South Florida · USCairo University · EGChildren's Mercy Hospital · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Defining the Role of Metabolic Heterogeneity in Melanoma Dissemination and Therapy EscapeR00CA226679 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SMALLEY, INNA · 2020 to 2022
$747k
Defining and targeting the immune-suppressive metabolic microenvironment of leptomeningeal melanoma metastasesR21CA274060 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SMALLEY, INNA · 2022 to 2023
$429k
NCI NIH HHS P30 CA076292NCI NIH HHS R00 CA226679NCI NIH HHS R21 CA274060
6 · The paper itself

Abstract

Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. The inaccessible nature of the disease site and lack of understanding of the biology of this unique metastatic site are major barriers to developing efficacious therapies for patients with melanoma LMD. Here, we characterize the tumor microenvironment of the leptomeningeal tissues and patient-matched extra-cranial metastatic sites using spatial transcriptomic analyses with

Indexed as

brainCSFleptomeningesmelanoma

Identifiers

PMID38187574
PMCPMC10769278
OpenAlexW4390026012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.