Evidence map›Paper›PMID 38187509›Full record

ArticleCardiology research2023

The Heart of Rett Syndrome: A Quantitative Analysis of Cardiac Repolarization.

Michael P Collins, Mark C Johnson, Robin C Ryther, Judith L Weisenberg, Peter T Heydemann, Colleen M Buhrfiend, William A Scott, Dallas M M Armstrong, Haley M Kern, Hoang H Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael P CollinsDepartment of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Mark C JohnsonDepartment of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Robin C RytherDepartment of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Judith L WeisenbergDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester NY, USA.
Peter T HeydemannDepartment of Pediatrics, Rush University Medical College, Chicago, IL, USA.
Colleen M BuhrfiendDepartment of Pediatrics, Rush University Medical College, Chicago, IL, USA.
William A ScottDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dallas M M ArmstrongDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Haley M KernDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hoang H NguyenDepartment of Pediatrics, Rush University Medical College, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rett syndrome (RTT) is a developmental encephalopathy disorder that is associated with a high incidence of sudden death presumably from cardiorespiratory etiologies. Electrocardiogram (ECG) abnormalities, such as prolonged heart-rate corrected QT (QTc) interval, are markers of cardiac repolarization and are associated with potentially lethal ventricular arrhythmias. This study investigates the cardiac repolarization characteristics of RTT patients, including QTc and T-wave morphology characteristics. Methods: A retrospective quantitative analysis on 110 RTT patients and 124 age and sex-matched healthy controls was conducted. Results: RTT patients had longer QTc, more abnormal T-wave morphology, and greater heterogeneity of cardiac repolarization parameters compared to controls. Even RTT patients without prolonged QTc had more abnormal ECG and T-wave characteristics than controls. Among RTT patients, Conclusions: Cardiac repolarization abnormalities are present in RTT patients, even without long QTc. T-wave morphology is related to RTT genotype and may be predictive of mortality. These findings could be used to help the management and monitoring of RTT patients.

Indexed as

Abnormal T waveCardiac repolarizationElectrocardiogramLong QTRett syndromeT-wave analysisVentricular repolarization

Identifiers

PMID38187509
PMCPMC10769616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.