Evidence map›Paper›PMID 38187392›Full record

ArticleFrontiers in immunology2023

The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol.

Michelle L Giles, Stephen Cole, Jessica O'Bryan, Sushena Krishnaswamy, Rym Ben-Othman, Nelly Amenyogbe, Mary-Ann Davey, Tobias Kollmann

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Michelle L GilesDepartment of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia.
Stephen ColeDepartment of Obstetrics and Gynaecology, Epworth Healthcare, Melbourne, VIC, Australia.
Jessica O'BryanDepartment of Infectious Diseases, Monash Health, Melbourne, VIC, Australia.
Sushena KrishnaswamyDepartment of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia.
Rym Ben-OthmanDepartment of Paediatrics, Telethon Kids, Perth, WA, Australia.
Nelly AmenyogbeDepartment of Paediatrics, Telethon Kids, Perth, WA, Australia.
Mary-Ann DaveyDepartment of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia.
Tobias KollmannDepartment of Paediatrics, Telethon Kids, Perth, WA, Australia.
The Kids Research Institute Australia · AUMonash University · AUEpworth Hospital · AUMonash Health · AURoyal Women's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal immunisation, a low cost and high efficacy intervention is recommended for its pathogen specific protection. Evidence suggests that maternal immunisation has another significant impact: reduction of preterm birth (PTB), the single greatest cause of childhood morbidity and mortality globally. Our overarching question is: how does maternal immunisation modify the immune system in pregnant women and/or their newborn to reduce adverse pregnancy outcomes and enhance the newborn infant's capacity to protect itself from infectious diseases during early childhood? To answer this question we are conducting a multi-site, prospective observational cohort study collecting maternal and infant biological samples at defined time points during pregnancy and post-partum from nulliparous women. We aim to enrol 400 women and determine the immune trajectory in pregnancy and the impact of maternal immunisation (including influenza, pertussis and/or COVID-19 vaccines) on this trajectory. The results are expected to identify areas that can be targeted for future intervention studies.

Indexed as

ImmunizationPremature BirthChild, PreschoolFemaleHumansImmunityInfantInfant, NewbornObservational Studies as TopicPregnancyProspective Studiesinfluenzapertussispregnancypreterm birthvaccination

Identifiers

PMID38187392
PMCPMC10771328
OpenAlexW4390013051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.