Evidence map›Paper›PMID 38186643›Full record

ArticleFrontiers in pharmacology2023

Cenobamate as add-on therapy for drug resistant epilepsies: effectiveness, drug to drug interactions and neuropsychological impact. What have we learned from real word evidence?

Nicola Pietrafusa, Giovanni Falcicchio, Emilio Russo, Simona Lattanzi, Bianca Goffredo, Raffaele Simeoli, Sara Cairoli, Tiziana Corsetti, Roberta Roberti, Marina De Tommaso and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Early sedation-related adverse events with the cenobamate-clobazam combination in drug-resistant epilepsy: real-world preliminary observations.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Drug-induced liver injury during valproic acid and cenobamate coadministration: a direct consequence or an unforeseen event?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  11. Cenobamate for Difficult-to-Treat Epilepsy - Selected Case Vignettes.Neuropsychiatric disease and treatment · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Nicola PietrafusaClinical and Experimental Neurology, Full Member of European Reference Network EpiCARE, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Giovanni FalcicchioDepartment of Translational Biomedicine and Neurosciences, University of Bari 'Aldo Moro', Bari, Italy.
Emilio RussoScience of Health Department, University Magna Grecia of Catanzaro, Catanzaro, Italy.
Simona LattanziNeurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Bianca GoffredoDivision of Metabolic Diseases and Drug Biology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Raffaele SimeoliDivision of Metabolic Diseases and Drug Biology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Sara CairoliDivision of Metabolic Diseases and Drug Biology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Tiziana CorsettiHospital Pharmacy Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Roberta RobertiScience of Health Department, University Magna Grecia of Catanzaro, Catanzaro, Italy.
Marina De TommasoDepartment of Translational Biomedicine and Neurosciences, University of Bari 'Aldo Moro', Bari, Italy.
Federico VigevanoHead of Neurological Sciences and Rehabilitation Medicine Scientific Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Angela La NeveDepartment of Translational Biomedicine and Neurosciences, University of Bari 'Aldo Moro', Bari, Italy.
Nicola SpecchioClinical and Experimental Neurology, Full Member of European Reference Network EpiCARE, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITBambino Gesù Children's Hospital · ITUniversity of Bari Aldo Moro · ITMagna Graecia University · ITMarche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

blood levelscenobamatedrug-resistanceepilepsyfocal-onset seizuresneuropsychology

Identifiers

PMID38186643
PMCPMC10768012
OpenAlexW4390056598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.