Evidence map›Paper›PMID 38185936›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2024

Mouse islet-derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function.

Wei Xu, Yunting Zhou, Tianyuan Wang, Chengming Ni, Chunlei Wang, Rui Li, Xuekui Liu, Jun Liang, Tzu-Wen Hong, Bo Liu and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Wei XuDepartment of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Medical University, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, China.ORCID https://orcid.org/0000-0003-2946-7897
Yunting ZhouDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Tianyuan WangEndocrinology Department, Air Force Hospital of Eastern Theater Command, Nanjing, China.
Chengming NiDepartment of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, China.
Chunlei WangDepartment of Endocrinology, Yancheng Clinical College of Xuzhou Medical University, Yanchen, China.
Rui LiDepartment of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Medical University, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, China.
Xuekui LiuDepartment of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Medical University, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, China.
Jun LiangDepartment of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Medical University, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, China.
Tzu-Wen HongDiabetes & Obesity, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK.
Bo LiuDiabetes & Obesity, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-8697-234X
Aileen J F KingDiabetes & Obesity, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0001-5759-7985
Shanta J PersaudDiabetes & Obesity, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK.
Zilin SunDepartment of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, China.ORCID https://orcid.org/0000-0003-1865-1429
Peter M JonesDiabetes & Obesity, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0003-1201-2335
King's College London · GBXuzhou Medical College · CNZhongda Hospital Southeast University · CNAir Force General Hospital PLA · CNNanjing Medical University · CN

Funding

Medical Research Council MR/W002876/1
6 · The paper itself

Abstract

aimsEvidence is accumulating of the therapeutic benefits of mesenchymal stromal cells (MSCs) in diabetes-related conditions. We have identified a novel population of stromal cells within islets of Langerhans - islet stellate cells (ISCs) - which have a similar morphology to MSCs. In this study we characterize mouse ISCs and compare their morphology and function to MSCs to determine whether ISCs may also have therapeutic potential in diabetes.

methodsISCs isolated from mouse islets were compared to mouse bone marrow MSCs by analysis of cell morphology; expression of cell-surface markers and extracellular matrix (ECM) components; proliferation; apoptosis; paracrine activity; and differentiation into adipocytes, chondrocytes and osteocytes. We also assessed the effects of co-culture with ISCs or MSCs on the insulin secretory capacity of islet beta cells.

resultsAlthough morphological similar, ISCs were functionally distinct from MSCs. Thus, ISCs were less proliferative and more apoptotic; they had different expression levels of important paracrine factors; and they were less efficient at differentiation down multiple lineages. Co-culture of mouse islets with ISCs enhanced glucose induced insulin secretion more effectively than co-culture with MSCs.

conclusionsISCs are a specific sub-type of islet-derived stromal cells that possess biological behaviors distinct from MSCs. The enhanced beneficial effects of ISCs on islet beta cell function suggests that they may offer a therapeutic target for enhancing beta cell functional survival in diabetes.

Indexed as

Cell DifferentiationCoculture TechniquesInsulin-Secreting CellsIslets of LangerhansMesenchymal Stem CellsAnimalsApoptosisCell ProliferationCells, CulturedInsulinInsulin SecretionMaleMiceMice, Inbred C57BLPancreatic Stellate CellsInsulindiabetes mellitusislets of Langerhansislet stellate cellsmesenchymal stromal/stem cells

Identifiers

PMID38185936
PMCPMC11451341
OpenAlexW4390666531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.