ArticleJournal of child psychology and psychiatry, and allied disciplines2024
Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Associations between transdiagnostic dimensions of psychopathology and brain structure and function in youth: What have we learned from the Adolescent Brain Cognitive Development (ABCD) study?Developmental cognitive neuroscience · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Relationships between wellbeing polygenic scores, brain structure, and psychopathology in children.medRxiv : the preprint server for health sciences · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWe used a polygenic score for externalizing behavior (extPGS) and structural MRI to examine potential pathways from genetic liability to conduct problems via the brain across the adolescent transition.
methodsThree annual assessments of child conduct problems, attention-deficit/hyperactivity problems, and internalizing problems were conducted across across 9-13 years of age among 4,475 children of European ancestry in the Adolescent Brain Cognitive Development
resultsThe extPGS predicted conduct problems in each wave (R
conclusionsAcross the adolescent transition, the extPGS predicted both variance specific to conduct problems and variance shared by all measured problems. The extPGS also was associated with TGMV, which robustly predicted conduct problems. Statistical mediation analyses suggested the hypothesis that polygenic variation influences individual differences in brain development that are related to the likelihood of conduct problems during the adolescent transition, justifying new research to test this causal hypothesis.
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Registered trials
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