Evidence map›Paper›PMID 38185848›Full record

ArticleJournal of neurotrauma2024

Perivascular Space Burden and Cerebrospinal Fluid Biomarkers in US Veterans With Blast-Related Mild Traumatic Brain Injury.

Erin A Yamamoto, Seiji Koike, Madison Luther, Laura Dennis, Miranda M Lim, Murray Raskind, Kathleen Pagulayan, Jeffrey Iliff, Elaine Peskind, Juan A Piantino

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Erin A YamamotoDepartment of Neurological Surgery, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA.
Seiji KoikeBiostatistics and Design Program, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA.
Madison LutherDepartment of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA.
Laura DennisDepartment of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA.
Miranda M LimVeterans Affairs VISN20 Northwest MIRECC, VA Portland Health Care System, Portland, Oregon, USA.
Murray RaskindVeterans Affairs (V.A.) Northwest (VISN 20) Mental Illness, Research, Education, and Clinical Center (MIRECC), Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
Kathleen PagulayanVeterans Affairs (V.A.) Northwest (VISN 20) Mental Illness, Research, Education, and Clinical Center (MIRECC), Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
Jeffrey IliffVeterans Affairs (V.A.) Northwest (VISN 20) Mental Illness, Research, Education, and Clinical Center (MIRECC), Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
Elaine PeskindVeterans Affairs (V.A.) Northwest (VISN 20) Mental Illness, Research, Education, and Clinical Center (MIRECC), Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
Juan A PiantinoDepartment of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA.
University of Washington · USOregon Health & Science University · US

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Jeffrey J Iliff · 2020 to 2026
$29.0M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
Defining the role of age-related glymphatic pathway impairment in amyloid beta plaque depositionR01AG054456 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI ILIFF, JEFFREY J · 2017 to 2021
$1.8M
Role of perivascular aquaporin-4 polarization in post-traumatic neurodegenerationR01NS089709 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI ILIFF, JEFFREY J · 2015 to 2019
$1.7M
A link between sleep-wake disturbances and enlarged perivascular spaces in youth with traumatic brain injuryK23HL150217 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI PIANTINO, JUAN ANDRES · 2020 to 2024
$826k
Mild TBI and Biomarkers of NeurodegenerationI01RX003087 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI PESKIND, ELAINE R. · 2019 to 2024
–
BLRD VA I01 BX006155CSRD VA I01 CX002022NHLBI NIH HHS K23 HL150217NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066518NIA NIH HHS R01 AG054456NINDS NIH HHS R01 NS089709RRD VA I01 RX003087
6 · The paper itself

Abstract

Blast-related mild traumatic brain injury (mTBI) is recognized as the "signature injury" of the Iraq and Afghanistan wars. Sleep disruption, mTBI, and neuroinflammation have been individually linked to cerebral perivascular space (PVS) dilatation. Dilated PVSs are putative markers of impaired cerebrospinal fluid (CSF) and interstitial fluid exchange, which plays an important role in removing cerebral waste. The aim of this cross-sectional, retrospective study was to define associations between biomarkers of inflammation and MRI-visible PVS (MV-PVS) burden in Veterans after blast-related mTBI (blast-mTBI) and controls. The CSF and plasma inflammatory biomarker concentrations were compared between blast-mTBI and control groups and correlated with MV-PVS volume and number per white matter cm

Indexed as

BiomarkersBlast InjuriesBrain ConcussionGlymphatic SystemVeteransAdultAfghan Campaign 2001-Cross-Sectional StudiesFemaleHumansIraq War, 2003-2011Magnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesUnited StatesBiomarkersbrain traumaglymphaticMRIneuroinflammationperivascular spaces

Identifiers

PMID38185848
PMCPMC11564836
OpenAlexW4390665557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.