Evidence map›Paper›PMID 38185720›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Biological and psychological predictors of cognitive function in breast cancer patients before surgery.

Snaefridur Gudmundsdottir Aspelund, Thorhildur Halldorsdottir, Gudjon Agustsson, Hannah Ros Sigurdardottir Tobin, Lisa M Wu, Ali Amidi, Kamilla R Johannsdottir, Susan K Lutgendorf, Rachel Telles, Huldis Franksdottir Daly and 3 more

Erratum issued Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04418856 (Light Therapy to Treat Cancer-related Fatigue, Sleep Problems, Depression and Cognitive Impairment Among Breast Cancer Patients.), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04418856 nacompletednot on this map

Light Therapy to Treat Cancer-related Fatigue, Sleep Problems, Depression and Cognitive Impairment Among Breast Cancer Patients.

TypeinterventionalSponsorReykjavik UniversityRan2020 to 2024Enrolled260ConditionsBreast Cancer, Circadian Rhythms, Fatigue, Sleep DisturbanceArmsLight Glasses (Experimental), Light Glasses (Comparison)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. A novel ecological momentary assessment app for the investigation of daily cognitive functioning in breast cancer survivors: a feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Snaefridur Gudmundsdottir AspelundDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Thorhildur HalldorsdottirDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Gudjon AgustssonDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Hannah Ros Sigurdardottir TobinDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Lisa M WuDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Ali AmidiUnit for Psycho-Oncology and Health Psychology, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark.
Kamilla R JohannsdottirDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Susan K LutgendorfDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.
Rachel TellesDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.
Huldis Franksdottir DalyDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Kristin SigurdardottirBreast Center, University Hospital of Iceland, Reykjavik, Iceland.
Heiddis B ValdimarsdottirDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland.
Birna BaldursdottirDepartment of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland. birnabaldurs@ru.is.
Reykjavík University · ISUniversity of Iowa · USAarhus University · DKNorthwestern University · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

purposeResearch suggests that cancer-related cognitive impairment (CRCI) can occur before breast cancer (BC) treatment. The limited extant evidence suggests the underlying mechanisms could be stress-related. Potential psychological and biological predictors of CRCI prior to any BC treatment were examined.

methods112 treatment-naïve women with BC and 67 healthy controls (HC) completed a neuropsychological test battery to assess cognitive impairment and a self-report battery to assess cognitive complaints, cancer-related stress, depressive and anxiety symptoms. Morning and evening cortisol and α-amylase were collected from saliva. Multilinear regressions were conducted.

resultsTreatment-naïve BC patients were more frequently impaired in verbal memory and processing speed and reported more cognitive complaints (all p < .001) than HC. BC patients and HC did not differ in overall cognitive impairment (p = .21). Steeper α-amylase, lower cancer-related stress and younger age was associated with better overall cognitive function in treatment-naïve BC patients. Higher depressive symptoms predicted higher levels of cognitive complaints in BC patients.

conclusionOverall, these findings suggest that stress plays a role in CRCI. This study is the first to associate α-amylase with cognitive function in cancer patients, informing future research. The findings on impairment in processing speed and verbal memory among treatment-naïve BC highlight the need to screen for such impairments among BC patients and indicate that future studies on CRCI should include baseline assessments prior to BC treatment. If replicated, these findings could inform the development and testing of appropriate interventions to decrease CRCI among cancer patients. CLINICAL TRIALS REGISTRATION NUMBER: NCT04418856, date of registration: 06.05.2020.

Indexed as

Breast NeoplasmsCognitive Dysfunctionalpha-AmylasesCognitionFemaleHumansHydrocortisonealpha-AmylasesHydrocortisoneA-amylaseBreast cancerCancer-related cognitive impairmentCognitive complaintsCortisolInternalizing symptomsTreatment-naïve

Identifiers

PMID38185720
OpenAlexW4390665832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.