ArticleNature communications2024
Silica-associated proteins from hexactinellid sponges support an alternative evolutionary scenario for biomineralization in Porifera.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Re-evaluating molecular clock maximum age calibrations revives pre-Ediacaran divergence estimates for animals.Science advances · 2026Article
- Co-option of Lysosomal Machinery for Sponge Biosilicification.bioRxiv : the preprint server for biology · 2026Article
- Innovations in Silicon Transport Shaped the Rise of Biosilicification and Skeletal Evolution in Sponges.Molecular biology and evolution · 2026Article
- Independent origins of spicules reconcile paleontological and molecular evidence of sponge evolutionary history.Science advances · 2026Article
- Data-driven inverse design of multifunctional bicontinuous multiscale structures.Nature communications · 2026Article
- Chemical characterization of CProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Phosphatic stromatoporoid sponges formed reefs ~480 Mya.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mineral Composition of Skeletal Elements in Dorid NudibranchiaBiomimetics (Basel, Switzerland) · 2025Article
- The chromosomal genome sequence of the sponge,Wellcome open research · 2025Article
- Silactins and Structural Diversity of Biosilica in Sponges.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- A late-Ediacaran crown-group sponge animal.Nature · 2024Article
- Biominerals and Bioinspired Materials in Biosensing: Recent Advancements and Applications.International journal of molecular sciences · 2024Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
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Abstract
Metazoans use silicon traces but rarely develop extensive silica skeletons, except for the early-diverging lineage of sponges. The mechanisms underlying metazoan silicification remain incompletely understood, despite significant biotechnological and evolutionary implications. Here, the characterization of two proteins identified from hexactinellid sponge silica, hexaxilin and perisilin, supports that the three classes of siliceous sponges (Hexactinellida, Demospongiae, and Homoscleromorpha) use independent protein machineries to build their skeletons, which become non-homologous structures. Hexaxilin forms the axial filament to intracellularly pattern the main symmetry of the skeletal parts, while perisilin appears to operate in their thickening, guiding extracellular deposition of peripheral silica, as does glassin, a previously characterized hexactinellid silicifying protein. Distant hexaxilin homologs occur in some bilaterians with siliceous parts, suggesting putative conserved silicifying activity along metazoan evolution. The findings also support that ancestral Porifera were non-skeletonized, acquiring silica skeletons only after diverging into major classes, what reconciles molecular-clock dating and the fossil record.
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