Evidence map›Paper›PMID 38185696›Full record

ArticleAIDS research and therapy2024

Effect of dolutegravir-based versus efavirenz-based antiretroviral therapy on excessive weight gain in adult treatment-naïve HIV patients at Matsanjeni health center, Eswatini: a retrospective cohort study.

Didier M Mukuna, Tom Decroo, Clara M Nyapokoto

Open access · goldAbstract read
In one paragraph

Article in AIDS research and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Didier M MukunaMinistry of Health, Matsanjeni Health Centre, ART Department, Matsanjeni, Eswatini. didier_mukuna@yahoo.com.
Tom DecrooUnit of HIV and TB, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Clara M NyapokotoEswatini National AIDS Program, Mbabane, Eswatini.
Instituut voor Tropische Geneeskunde · BEMinistry of Health · SZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition.

methodsIn Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m

resultsThe median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m

conclusionPractitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.

Indexed as

HIV InfectionsAdultAlkynesBenzoxazinesCyclopropanesDolutegravirEswatiniHumansRetrospective StudiesWeight GainAlkynesBenzoxazinesCyclopropanesDolutegravirefavirenzDolutegravirEfavirenzExcessive weight gainMatsanjeni health centre

Identifiers

PMID38185696
PMCPMC10771685
OpenAlexW4390651446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.