ArticleBMC plant biology2024
Utilizing transcriptomics and metabolomics to unravel key genes and metabolites of maize seedlings in response to drought stress.
Article in BMC plant biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 40 citations in OpenAlex.
- Problems With GO Enrichment as an Endpoint for Ecological Omics Interpretation.Molecular ecology · 2026Article
- Comparative metabolomic analysis of leaves and kernels in wild type andFood chemistry. Molecular sciences · 2026Article
- Multi-Omics Dissection of Drought Stress Responses in Crops: From Molecular Regulatory Networks to Climate-Resilient Breeding Applications.International journal of molecular sciences · 2026Review
- Integrated transcriptome and metabolome analysis reveals the molecular mechanisms of drought response in Setaria italica during the booting stage.BMC plant biology · 2026Article
- Integrated ion, hormone, and proteomic analyses reveal the mechanisms of drought resistance in alfalfa (Medicago sativa).BMC plant biology · 2026Article
- Article
- Tissue-specific metabolomic profiling reveals cultivar-dependent drought tolerance mechanisms in rice (Oryza sativa L.).BMC plant biology · 2026Article
- Responses and adaptations of plants to abiotic stress: transcriptional regulation of secondary metabolic pathways, metabolomics, and nanobiological approaches.Frontiers in genetics · 2026Review
- From development to yield: genetic and molecular regulation of agronomic traits in maize seeds.Frontiers in plant science · 2026Review
- Metabolic response strategies of spring wheat under osmotic stress.Frontiers in plant science · 2026Article
- All roads lead to Rome: integrated physiological and transcriptomic analysis of cacao drought response reveals different ways to achieve tolerance in two hybrid clones.Frontiers in plant science · 2026Article
- Leaf structure, physiology and transcriptome response of ancientOpen life sciences · 2026Article
- Co-expression analysis provides a new strategy for mining key metabolites and genes in response to drought stress in Agropyron mongolicum.Plant molecular biology · 2025Article
- Widely targeted metabolic profiling reveals drought resistance mechanisms in alfalfa leaves.BMC plant biology · 2025Article
- Advances in Functional Genomics for Exploring Abiotic Stress Tolerance Mechanisms in Cereals.Plants (Basel, Switzerland) · 2025Review
- Progress in Transcriptomics and Metabolomics in Plant Responses to Abiotic Stresses.Current issues in molecular biology · 2025Review
- Integrative multi-omics analysis reveals the potential mechanism by which Streptomyces pactum Act12 enhances wheat root drought tolerance by coordinating phytohormones and metabolic pathways.BMC plant biology · 2025Article
- Nitrogen cycle induced by plant growth-promoting rhizobacteria drives "microbial partners" to enhance cadmium phytoremediation.Microbiome · 2025Article
- Comparative transcriptome and metabolome profiling unveil genotype-specific strategies for drought tolerance in cotton.Frontiers in plant science · 2025Article
- Functional study of ZmHDZ4 in maize (Zea mays) seedlings under drought stress.BMC plant biology · 2024Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDrought stress can substantially restrict maize growth and productivity, and global warming and an increasing frequency of extreme weather events are likely to result in more yield losses in the future. Therefore, unraveling the molecular mechanism underlying the response to drought stress is essential for breeding drought-resilient crops.
resultsIn this study, we subjected the 3-leaf-period plants of two maize inbred lines, a drought-tolerant line (si287) and a drought-sensitive line (X178), to drought stress for seven days while growing in a chamber. Subsequently, we measured physiological traits and analyzed transcriptomic and metabolic profiles of two inbred lines. Our KEGG analysis of genes and metabolites revealed significant differences in pathways related to glycolysis/gluconeogenesis, flavonoid biosynthesis, starch and sucrose metabolism, and biosynthesis of amino acids. Additionally, our joint analysis identified proline, tryptophan and phenylalanine are crucial amino acids for maize response to drought stress. Furthermore, we concentrated on tryptophan (Trp), which was found to enhance tolerance via IAA-ABA signaling, as well as SA and nicotinamide adenine dinucleotide (NAD) consequent reactive oxygen species (ROS) scavenging. We identified three hub genes in tryptophan biosynthesis, indole-3-acetaldehyde oxidase (ZmAO1, 542,228), catalase 1 (ZmCAT1, 542,369), and flavin-containing monooxygenase 6 (ZmYUC6, 103,629,142), High expression of these genes plays a significant role in regulating drought tolerance. Two metabolites related to tryptophan biosynthesis, quinolinic acid, and kynurenine improved maize tolerance to drought stress by scavenging reactive oxygen species.
conclusionsThis study illuminates the mechanisms underlying the response of maize seedlings to drought stress. Especially, it identifies novel candidate genes and metabolites, enriching our understanding of the role of tryptophan in drought stress. The identification of distinct resistance mechanisms in maize inbred lines will facilitate the exploration of maize germplasm and the breeding of drought-resilient hybrids.
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