Evidence map›Paper›PMID 38185538›Full record

Trial reportEuropean urology2024

Safety Analyses of the Phase 3 VISION Trial of [

Kim N Chi, Andrew J Armstrong, Bernd J Krause, Ken Herrmann, Kambiz Rahbar, Johann S de Bono, Nabil Adra, Rohan Garje, Jeff M Michalski, Mette M Kempel and 8 more

Registry-linked trialAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in European urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03511664 (VISION), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03511664 phase3completednot on this map

VISION: An International, Prospective, Open Label, Multicenter, Randomized Phase 3 Study of 177Lu-PSMA-617 in the Treatment of Patients With Progressive PSMA-positive Metastatic Castration-resistant Prostate Cancer (mCRPC)

TypeinterventionalSponsorEndocyteRan2018 to 2023Enrolled861ConditionsProstate CancerArms177Lu-PSMA-617, Best supportive/best standard of care
3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Final overall survival and safety analyses of the phase III PSMAfore trial of [Annals of oncology : official journal of the European Society for Medical Oncology · 2025
    Trial
  2. Review
  3. Real-world evaluation of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Review
  5. Outcome-driven dosimetry optimization for [European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Efficacy, safety, and quality of life outcomes of [International urology and nephrology · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Frailty and [Theranostics · 2026
    Review
  13. Review
  14. Review
  15. Molecules (Basel, Switzerland) · 2025
    Review
  16. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  17. Development of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  18. Biodistribution and dosimetry of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kim N ChiBritish Columbia Cancer, Vancouver Prostate Centre, Vancouver, Canada. Electronic address: kchi@bccancer.bc.ca.
Andrew J ArmstrongDuke Cancer Institute Center for Prostate & Urologic Cancers, Duke University, Durham, NC, USA.
Bernd J KrauseDepartment of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany.
Ken HerrmannDepartment of Nuclear Medicine, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany.
Kambiz RahbarDepartment of Nuclear Medicine, University Hospital Münster, Münster, Germany.
Johann S de BonoDivision of Clinical Studies, The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.
Nabil AdraIndiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.
Rohan GarjeMiami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.
Jeff M MichalskiDepartment of Radiation Oncology, Washington University, St. Louis, MO, USA.
Mette M KempelDepartment of Oncology and Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
Karim FizaziDepartment of Cancer Medicine, Institut Gustave Roussy, University of Paris-Saclay, Villejuif, France.
Michael J MorrisGenitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Oliver SartorTulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA.
Marcia BrackmanNovartis Pharmaceuticals Corporation, Indianapolis, IN, USA.
Michelle DeSilvioNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
Celine WilkeNovartis Pharma AG, Basel, Switzerland.
Geoffrey HolderNovartis Pharma AG, Basel, Switzerland.
Scott T TagawaHematology and Medical Oncology Department, Weill Cornell Medicine, New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

BACKGROUND AND

objective[

methodsVISION was an international, open-label study. Patients were randomised 2:1 to receive KEY FINDINGS AND LIMITATIONS: The any-grade TEAE incidence was similar in cycles 1-4 and cycles 5-6. TEAE frequency was similar across all cycles of CONCLUSIONS AND CLINICAL IMPLICATIONS: Longer exposure to PATIENT SUMMARY: For patients with metastatic prostate cancer no longer responding to hormone therapy, an increase in the number of cycles of treatment with a radioactive compound called

Indexed as

DipeptidesHeterocyclic Compounds, 1-RingProstatic Neoplasms, Castration-ResistantHumansLutetiumMaleProstate-Specific AntigenRadiopharmaceuticalsTreatment OutcomeDipeptidesHeterocyclic Compounds, 1-RingLutetiumProstate-Specific AntigenPSMA-617Radiopharmaceuticals(177)Lu-PSMA-617Metastatic castration-resistant prostate cancerRadioligand therapyTreatment-emergent adverse eventsTreatment exposure

Identifiers

PMID38185538
PMCPMC11859717

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.