Evidence map›Paper›PMID 38185323›Full record

ArticleJournal of molecular biology2024

Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant.

Sebastian Kenny, Chih-Hsuan Lai, Tsung-Sheng Chiang, Kwame Brown, Chad S Hewitt, Aaron D Krabill, Hao-Ting Chang, Yong-Sheng Wang, Daniel P Flaherty, Shang-Te Danny Hsu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Sebastian KennyDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, United States.
Chih-Hsuan LaiInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Tsung-Sheng ChiangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
Kwame BrownDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, United States.
Chad S HewittBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47906, United States.
Aaron D KrabillBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47906, United States.
Hao-Ting ChangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
Yong-Sheng WangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
Daniel P FlahertyBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47906, United States.
Shang-Te Danny HsuInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan; International Institute for Sustainability with Knotted Chiral Meta Matter (WPI-SKCM(2)), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan. Electronic address: sthsu@gate.sinica.edu.tw.
Chittaranjan DasDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, United States. Electronic address: cdas@purdue.edu.
Purdue University West Lafayette · USNational Taiwan University · TWHiroshima University · JPInstitute of Biological Chemistry, Academia Sinica · TW

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Mechanism of atypical ubiquitination and deubiquitination by bacterial effectorsR01GM126296 · NIGMS · PURDUE UNIVERSITY · PI Chittaranjan Das · 2018 to 2026
$3.6M
Purdue University Molecular Biophysics Training ProgramT32GM132024 · NIGMS · PURDUE UNIVERSITY · PI Angeline Marie Lyon, John Tesmer · 2019 to 2026
$2.0M
NCI NIH HHS P30 CA023168NIGMS NIH HHS R01 GM126296NIGMS NIH HHS T32 GM132024
6 · The paper itself

Abstract

A mutant of ubiquitin C-terminal hydrolase L1 (UCHL1) detected in early-onset neurodegenerative patients, UCHL1

Indexed as

Catalytic DomainCysteineNeurodegenerative DiseasesUbiquitin ThiolesteraseBinding SitesHumansKineticsMutagenesis, Site-DirectedNuclear Magnetic Resonance, BiomolecularScattering, Small AngleX-Ray DiffractionCysteineUbiquitin ThiolesteraseUCHL1 protein, human

Identifiers

PMID38185323
PMCPMC11488486
OpenAlexW4390618684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.