Evidence map›Paper›PMID 38185107›Full record

Trial reportObesity facts2024

Helpful to Live Healthier? Intermittent Hypoxic/Ischemic Training Benefits Vascular Homeostasis and Lipid Metabolism with Activating SIRT1 Pathways in Overweight/Obese Individuals.

Xueqiao Jiao, Moqi Liu, Rui Li, Jialu Li, Lu Wang, Guowei Niu, Liming Wang, Xunming Ji, Chunmei Lv, Xiuhai Guo

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity facts, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xueqiao JiaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Moqi LiuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Rui LiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jialu LiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Lu WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Guowei NiuDepartment of Medicine, Beijing Xiaotangshan Hospital, Beijing, China.
Liming WangDepartment of Medicine, Beijing Xiaotangshan Hospital, Beijing, China.
Xunming JiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chunmei LvDepartment of Medicine, Beijing Xiaotangshan Hospital, Beijing, China.
Xiuhai GuoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe present study aimed to investigate whether and how normobaric intermittent hypoxic training (IHT) or remote ischemic preconditioning (RIPC) plus normoxic training (RNT) has a synergistic protective effect on lipid metabolism and vascular function compared with normoxic training (NT) in overweight or obese adults.

methodsA total of 37 overweight or obese adults (36.03 ± 10.48 years) were randomly assigned to 3 groups: NT group (exercise intervention in normoxia), IHT group (exercise intervention in normobaric hypoxic chamber), and RNT group (exercise intervention in normoxia + RIPC twice daily). All participants carried out the same 1-h exercise intervention for a total of 4 weeks, 5 days per week. Physical fitness parameters were evaluated at pre- and postexercise intervention.

resultsAfter training, all three groups had a significantly decreased body mass index (p < 0.05). The IHT group had reduced body fat percentage, visceral fat mass (p < 0.05), blood pressure (p < 0.01), left ankle-brachial index (ABI), maximal heart rate (HRmax) (p < 0.05), expression of peroxisome proliferator-activated receptor-γ (PPARγ) (p < 0.01) and increased expression of SIRT1 (p < 0.05), VEGF (p < 0.01). The RNT group had lowered waist-to-hip ratio, visceral fat mass, blood pressure (p < 0.05), and HRmax (p < 0.01).

conclusionIHT could effectively reduce visceral fat mass and improve vascular elasticity in overweight or obese individuals than pure NT with the activation of SIRT1-related pathways. And RNT also produced similar benefits on body composition and vascular function, which were weaker than those of IHT but stronger than NT. Given the convenience and economy of RNT, both intermittent hypoxic and ischemic training have the potential to be successful health promotion strategies for the overweight/obese population.

Indexed as

Lipid MetabolismOverweightAdultHomeostasisHumansObesitySirtuin 1SIRT1 protein, humanSirtuin 1Intermittent hypoxic trainingLipid metabolismObesity managementRemote ischemic preconditioningVascular homeostasis

Identifiers

PMID38185107
PMCPMC10987187
OpenAlexW4390605621

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.