Evidence map›Paper›PMID 38185099›Full record

ArticleBlood purification2024

Prognostic Factors in Children with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy.

Jhao-Jhuang Ding, Shao-Hsuan Hsia, Tang-Her Jaing, Jing-Long Huang, Jainn-Jim Lin, Shih-Hsiang Chen, Shih-Hua Lin, Min-Hua Tseng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood purification, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jhao-Jhuang DingDepartment of Pediatrics, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan.
Shao-Hsuan HsiaDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Tang-Her JaingDivision of Hematology/Oncology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Jing-Long HuangDepartment of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Jainn-Jim LinDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Shih-Hsiang ChenDivision of Hematology/Oncology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Shih-Hua LinDivision of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Min-Hua TsengDivision of Nephrology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to evaluate prognostic factors and outcomes in a single-center PICU cohort that received continuous renal replacement therapy (CRRT).

methodsThis retrospective study analyzed clinical characteristics, laboratory data, and outcomes. Ninety-day mortality and advanced chronic kidney disease (CKD) (eGFR <60 mL/min/1.73 m2) were defined as primary and secondary outcomes, respectively.

resultsSeventy-five patients were enrolled, all of whom received CRRT for indications including acute kidney injury with complicated refractory metabolic acidosis, electrolyte derangement, and existed or impending fluid overload. The 90-day mortality and advanced CKD were 53% and 29%, respectively. Multivariate Cox regression analysis demonstrated that only underlying bone marrow transplantation (BMT) (HR 4.58; 95% CI: 2.04-10.27) and a high pSOFA score (HR 1.12; 95% CI: 1.01-1.23) were independent risk factors for 90-day mortality. Among survivors, ten developed advanced CKD on the 90th day, and this group had a higher serum fibrinogen level (OR 1.01; 95% CI: 1.01-1.03) at the start of CRRT.

conclusionIn critically ill children with AKI requiring CRRT, post-BMT and high pSOFA scores are independent risk factors for 90-day mortality. Additionally, a high serum fibrinogen level at the initiation of CRRT is associated with the development of advanced CKD.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyAdolescentBone Marrow TransplantationChildChild, PreschoolCritical IllnessFemaleHumansInfantMalePrognosisRenal Insufficiency, ChronicRenal Replacement TherapyRetrospective StudiesRisk FactorsAcute kidney injuryBone marrow transplantationContinuous renal replacement therapyFibrinogenMulti-organ dysfunctionPediatrics

Identifiers

PMID38185099
PMCPMC11151997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.