Evidence map›Paper›PMID 38185059›Full record

ArticleTranslational oncology2024

The Rac1-inhibitor EHop-016 attenuates AML cell migration and enhances the efficacy of daunorubicin in MOLM-13 transplanted zebrafish larvae.

Anette Lodvir Hemsing, Jan-Lukas Førde, Håkon Reikvam, Lars Herfindal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anette Lodvir HemsingDepartment of Medicine, Haukeland University Hospital, pb 1400, Bergen 5021, Norway; Department of Clinical Science, University of Bergen, Jonas Lies vei 87, Bergen 5021, Norway.
Jan-Lukas FørdeDepartment of Medicine, Haukeland University Hospital, pb 1400, Bergen 5021, Norway; Centre for Pharmacy, Department of Clinical Science, University of Bergen, Jonas Lies vei 87, Bergen 5021, Norway.
Håkon ReikvamDepartment of Medicine, Haukeland University Hospital, pb 1400, Bergen 5021, Norway; Department of Clinical Science, University of Bergen, Jonas Lies vei 87, Bergen 5021, Norway.
Lars HerfindalCentre for Pharmacy, Department of Clinical Science, University of Bergen, Jonas Lies vei 87, Bergen 5021, Norway. Electronic address: lars.herfindal@uib.no.
Haukeland University Hospital · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ras-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase implicated in cell migration and homing of hematopoietic cells to the hematopoietic niche, and is commonly overexpressed in acute myeloid leukemia (AML). This can lead to quiescence of leukemic blasts in the niche and reduced response to therapy. We investigated the Rac1 inhibitor EHop-016 on AML by assessing its effects on MOLM-13 cells in vitro and in zebrafish larvae, regarding cell motility and therapeutic potential in combination with daunorubicin (DNR). In vitro assessment of proliferation and viability was by measurement of

Indexed as

AMLCell migrationHomingRac1TherapyZebrafish larvae

Identifiers

PMID38185059
PMCPMC10818244
OpenAlexW4390644194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.