Evidence map›Paper›PMID 38185046›Full record

ArticleEnvironment international2024

Traffic-related air pollution and dementia incidence in the Adult Changes in Thought Study.

Magali N Blanco, Rachel M Shaffer, Ge Li, Sara D Adar, Marco Carone, Adam A Szpiro, Joel D Kaufman, Timothy V Larson, Anjum Hajat, Eric B Larson and 2 more

Open access · goldAbstract read
In one paragraph

Article in Environment international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Systematic review and meta-analysis on the health effects of long-term exposure to ultrafine particles.European respiratory review : an official journal of the European Respiratory Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Magali N BlancoDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: magali@uw.edu.
Rachel M ShafferDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Ge LiVA Northwest Network Mental Illness Research, Education, and Clinical Center, Virginia Puget Sound Health Care System, Seattle, WA, USA; Geriatric Research, Education, and Clinical Center, Virginia Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
Sara D AdarDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Marco CaroneDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Adam A SzpiroDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
Timothy V LarsonDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Civil & Environmental Engineering, University of Washington, Seattle, WA, USA.
Anjum HajatDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Eric B LarsonDepartment of Medicine, University of Washington, Seattle, WA, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Lianne SheppardDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
University of Washington · USUniversity of Michigan · USUniversity of Puget Sound · US

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Biostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6M
Air Pollution, the Aging Brain and Alzheimer's DiseaseR01ES026187 · NIEHS · UNIVERSITY OF WASHINGTON · PI LI, GAIL, SHEPPARD, ELIZABETH A LIANNE · 2016 to 2020
$3.8M
NIA NIH HHS U19 AG066567NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES026187NIEHS NIH HHS T32 ES015459
6 · The paper itself

Abstract

backgroundWhile epidemiologic evidence links higher levels of exposure to fine particulate matter (PM

objectiveTo evaluate associations between TRAP exposures (UFP, black carbon [BC], and nitrogen dioxide [NO

methodsWe ascertained dementia incidence in the Seattle-based Adult Changes in Thought (ACT) prospective cohort study (beginning in 1994) and assessed ten-year average TRAP exposures for each participant based on prediction models derived from an extensive mobile monitoring campaign. We applied Cox proportional hazards models to investigate TRAP exposure and dementia incidence using age as the time axis and further adjusting for sex, self-reported race, calendar year, education, socioeconomic status, PM

resultsWe identified 1,041 incident all-cause dementia cases in 4,283 participants over 37,102 person-years of follow-up. We did not find evidence of a greater hazard of late-life dementia incidence with elevated levels of long-term TRAP exposures. The estimated hazard ratio of all-cause dementia was 0.98 (95 % CI: 0.92-1.05) for every 2000 pt/cm DISCUSSION: We did not find evidence of a greater hazard of late-life dementia risk with elevated long-term TRAP exposures in this population-based prospective cohort study.

Indexed as

Air PollutantsAir PollutionDementiaAdultEnvironmental ExposureHumansIncidenceNitrogen DioxideParticulate MatterProspective StudiesAir PollutantsNitrogen DioxideParticulate MatterAlzheimer’s Disease (AD) and related dementias (ADRD)Black carbon (BC)CohortNitrogen dioxide (NO2) traffic-related air pollutionUltrafine particles (UFP)

Identifiers

PMID38185046
PMCPMC10873482
OpenAlexW4390572125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.