Evidence map›Paper›PMID 38184622›Full record

ArticleSystematic reviews2024

Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis.

Emily Sirotich, Hasmik Nazaryan, Saifur Rahman Chowdhury, Gordon Guyatt, Arnav Agarwal, Russell Leong, Aaron Wen, Emily Xu, Bonnie Liu, Sushmitha Pallapothu and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Analysis of Risk Factors and the Establishment of a Predictive Model for Thrombosis in Patients with Immune Thrombocytopenia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Emily Sirotich *Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-7087-8543
Hasmik Nazaryan *Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Saifur Rahman ChowdhuryMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Gordon GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Arnav AgarwalDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Russell LeongFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Aaron WenMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Emily XuMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Bonnie LiuMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Sushmitha PallapothuDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Preksha RathodMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Henry Y KwonDepartment of Surgery, Henry Ford Health Systems, Detroit, MI, USA.
Jared DookieMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Amirmohammad ShafieeMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
Jay CharnessPlatelet Disorder Support Association (PDSA), Cleveland, OH, USA.
Jennifer DiRaimoPlatelet Disorder Support Association (PDSA), Cleveland, OH, USA.
Dale PaynterPlatelet Disorder Support Association (PDSA), Cleveland, OH, USA.
Barbara PruittPlatelet Disorder Support Association (PDSA), Cleveland, OH, USA.
Gail StrachanPlatelet Disorder Support Association (PDSA), Cleveland, OH, USA.
Rachel CoubanFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Zhikang YeDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Donald M ArnoldMichael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada. arnold@mcmaster.ca.
McMaster University · CAImpact · CAHenry Ford Health System · USUniversity of Ottawa · CA

Funding

CIHR 165811
6 · The paper itself

Abstract

backgroundCritical bleeding events in adults and children with ITP are medical emergencies; however, evidence-based treatment protocols are lacking. Due to the severe thrombocytopenia, (typically platelet count less than 20 × 10

methodsLiterature searches will be conducted in four electronic databases: Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and PubMed. Eligible studies will be randomized controlled trials or observational studies that enrolled patients with ITP describing one or more interventions for the management of critical bleeding. Title and abstract screening, full-text screening, data extraction, and risk of bias evaluation will be conducted independently and in duplicate using Covidence and Excel. Outcomes will be pooled for meta-analysis where appropriate or summarized descriptively. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology will be used to evaluate the certainty of the evidence. Primary outcomes of interest will include frequency of critical bleeds, mortality and bleeding-related mortality, bleeding resolution, platelet count, and disability. DISCUSSION: Evidence-based treatments for critical bleeding in patients with ITP are needed to improve patient outcomes and standardize care in the emergency setting. SYSTEMATIC REVIEW REGISTRATION: CRD42020161206.

Indexed as

HemorrhagePurpura, Thrombocytopenic, IdiopathicAdultChildHumansMeta-Analysis as TopicSystematic Reviews as TopicThrombocytopeniaCritical bleedingEmergency managementImmune thrombocytopeniaThrombocytopenia

Identifiers

PMID38184622
PMCPMC10770981
OpenAlexW4390640778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.