ArticleCardiovascular diabetology2024
Glycemic control and cardiovascular outcomes in patients with diabetes and coronary artery disease according to triglyceride-glucose index: a large-scale cohort study.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Does diabetes status modify the association between the triglyceride-glucose index and major adverse cardiovascular events in patients with coronary heart disease? A systematic review and meta-analysis of longitudinal cohort studies.Cardiovascular diabetology · 2025Pooled it
- Does diabetes modify the triglyceride-glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants.Cardiovascular diabetology · 2025Pooled it
- Synergistic effects of insulin resistance and revascularization completeness on prognosis in patients with coronary artery calcification.Cardiovascular diabetology · 2026Observational
- Joint association of weekend catch-up sleep and triglyceride-glucose index on bone loss and all-cause mortality in employed U.S. adults aged 18-60 with diabetes.Lipids in health and disease · 2026Article
- Determinants of Poor Glycemic Control in Type 2 Diabetes Patients With Coronary Artery Disease: A Case-Control Study.Health science reports · 2026Article
- Diabetes Mellitus Duration and Major Adverse Cardiovascular Events Following Percutaneous Coronary Intervention: A Prospective Cohort Study.International journal of vascular medicine · 2026Article
- Triglyceride-glucose index at ICU admission predicts hospital mortality in patients with acute coronary syndrome concomitant sepsis: a Bayesian network analysis of retrospective multicenter cohort study.Frontiers in nutrition · 2026Article
- Article
- Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus.The Journal of international medical research · 2025Article
- Prediction of Percutaneous Coronary Intervention Success in Patients With Moderate to Severe Coronary Artery Calcification Using Machine Learning Based on Coronary Angiography: Prospective Cohort Study.Journal of medical Internet research · 2025Article
- Article
- Effectiveness of a theory-based tailored individual and family self-management education in adults with uncontrolled diabetes: A randomized controlled trial.International journal of nursing sciences · 2025Article
- Development and validation of a novel glucolipid metabolism-related nomogram to enhance the predictive performance for osteoporosis complications in prediabetic and diabetic patients.Lipids in health and disease · 2025Article
- Secondary Prevention After Acute Coronary Syndromes in Women: Tailored Management and Cardiac Rehabilitation.Journal of clinical medicine · 2025Review
- Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.Lipids in health and disease · 2025Article
- Development and validation of a novel metabolic health-related nomogram to improve predictive performance of cardiovascular disease risk in patients with prediabetes.Lipids in health and disease · 2025Article
- Evaluation of the effects of short-term PMBMC cardiovascular disorders · 2025Article
- The Impact of Triglyceride-Glucose Index Trajectories on Incidence and Recurrent Cardiovascular Events: Evidence from a Retrospective Cohort Study.Vascular health and risk management · 2025Article
- Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study.Open medicine (Warsaw, Poland) · 2025Article
- Association between triglyceride-glucose index and subclinical carotid atherosclerosis in systemic lupus erythematosus: a cohort-based study.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe role of triglyceride-glucose (TyG) index, an insulin resistance indicator, in glycemic management for diabetic patients with coronary artery disease (CAD) was still unknown. Therefore, we aimed to explore the association between glycemic control and cardiovascular (CV) outcomes in patients with diabetes and CAD according to different TyG index levels.
methodsA total of 9996 diabetic patients with angiograph-proven CAD were consecutively recruited from 2017 to 2018 at Fuwai Hospital. Patients were assigned into 3 groups according to TyG index tertiles (T) (T1: <8.895; T2: 8.895-9.400; T3: ≥9.400). According to American Diabetes Association guidelines, controlled glycemia was defined as targeting glycosylated hemoglobin Alc (HbA1c) < 7%. The primary endpoint was CV events including CV death, nonfatal myocardial infarction, and nonfatal stroke.
resultsDuring a median 3-year follow-up, 381 (3.8%) CV events occurred. Overall, high TyG index (T3) was associated with increased risk of CV events (hazard ratio [HR]: 1.40; 95% confidence interval [CI]: 1.02-1.94) compared with the lowest TyG index (T1) after multivariable adjustment. Upon stratification by the TyG index, in fully adjusted models, controlled glycemia was associated with reduced risk of CV events in the high TyG index (T3) subgroup (HR: 0.64; 95%CI: 0.42-0.96) but not in the low (T1; HR: 0.79; 95%CI: 0.53-1.16) and moderate (T2; HR: 0.84; 95%CI: 0.56-1.25) TyG index subgroups.
conclusionsControlled glycemia was associated with improved CV outcomes in patients with diabetes and established CAD, especially in those with high TyG index levels. Our study, for the first time, provided valuable information that TyG index could help making risk stratification on the glycemic management in diabetic patients with CAD.
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