Evidence map›Paper›PMID 38184457›Full record

ArticleInternational dental journal2024

Role of YAP in Odontoblast Damage Repair in a Dentin Hypersensitivity Model.

Xiangyao Tong, Yijie Wang, Hui Zhang, Peiqi Liu, Chenxu Wang, Huizhe Liu, Rui Zou, Lin Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiangyao TongKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yijie WangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Xi'an Jiaotong University Health Science Center, Xi'an, China.
Hui ZhangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, China.
Peiqi LiuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Xi'an Jiaotong University Health Science Center, Xi'an, China.
Chenxu WangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Xi'an Jiaotong University Health Science Center, Xi'an, China.
Huizhe LiuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Xi'an Jiaotong University Health Science Center, Xi'an, China.
Rui ZouKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Xi'an Jiaotong University Health Science Center, Xi'an, China. Electronic address: rainy@mail.xjtu.edu.cn.
Lin NiuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Xi'an Jiaotong University Health Science Center, Xi'an, China. Electronic address: niulin@mail.xjtu.edu.cn.
Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the molecular mechanism underlying odontoblast damage repair in dentin hypersensitivity (DH) and the role of Yes-associated protein (YAP) in this process.

methodsThe DH model was constructed in Sprague-Dawley (SD) rats, and the in vivo expression of Piezo1, Integrin αvβ3, YAP, and dentin sialophosphoprotein (DSPP) was detected by immunohistochemistry. COMSOL Multiphysics software was used to simulate the dentinal tubule fluid flow velocity and corresponding fluid shear stress (FSS) on the odontoblast processes. MDPC-23 cells were cultured in vitro and loaded with a peristaltic pump for 1 hour at FSS values of 0.1, 0.3, 0.5, and 0.7 dyne/cm

resultsThe level and duration of external mechanical stimuli have an effect on the functional expression of odontoblasts. In DH, the harder the food that is chewed, the faster the flow of the dentinal tubule fluid and the greater the FSS on the odontoblast processes. The expression of Piezo1, Integrin αvβ3, and YAP can be promoted when the FSS is less than 0.3 dyne/cm

conclusionsThese results suggest that appropriate FSS can enhance the expression of odontoblast-related factors in odontoblasts via the Piezo1-Integrin αvβ3-YAP mechanotransduction pathway and the YAP appears to play an essential role in the response of odontoblasts to external mechanical stimuli.

Indexed as

Dentin SensitivityOdontoblastsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAnimalsDentin SialophosphoproteinDisease Models, AnimalExtracellular Matrix ProteinsImmunohistochemistryIntegrin alphaVbeta3Ion ChannelsMembrane ProteinsPhosphoproteinsRatsRats, Sprague-DawleySialoglycoproteinsAdaptor Proteins, Signal TransducingDentin SialophosphoproteinExtracellular Matrix ProteinsIntegrin alphaVbeta3Ion ChannelsMembrane ProteinsPhosphoproteinsPiezo1 protein, ratSialoglycoproteinsVerteporfinYap1 protein, ratYAP-Signaling ProteinsDamage repairDentin hypersensitivityFluid shear stressOdontoblastsYAP

Identifiers

PMID38184457
PMCPMC11123538
OpenAlexW4390617448

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.