ReviewJournal of neurochemistry2024
Brain energy metabolism: A roadmap for future research.
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In one paragraph
Review in Journal of neurochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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47citing papers in PubMed, 1 pooled it
21.3field-weighted citation impact, top 1% of its field
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Neuropeptide Y and brain ageing: an updated scoping review on the role of autophagy.Frontiers in aging neuroscience · 2026Pooled it
- Molecular pathways linking traumatic brain injury to cardiovascular dysfunction: therapeutic potential of physical exercise.Metabolic brain disease · 2026Review
- Pentose Phosphate Pathway Is Critical for Providing Energy by Bypassing 6-Phosphofructo-1-Kinase (PFK1) During Increased Neuronal Activity.Metabolites · 2026Review
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- Brain energetic landscapes shape state dysregulation in major depressive disorder: a morphological network controllability perspective.Translational psychiatry · 2026Article
- Anxiety Disorder Types From a Metabolomics Perspective: A Mendelian Randomization Analysis Based on 1400 Plasma Metabolites.Brain and behavior · 2026Article
- 3-Methylcrotonyl-CoA Carboxylase Expression Among Astrocytes and Neurons in the Human Brain and the Effect of Hyperglycemia on the Catabolic Flux ofNeurochemical research · 2026Article
- Optimizing Brain Biology Through Near-Infrared-Induced Mitochondrial Melatonin Synthesis: A Hypothesis Paper.Cureus · 2026Review
- Role of mitochondria in neuronal function and survival in the enteric and central nervous systems.Cellular and molecular life sciences : CMLS · 2026Review
- Brain glucodynamic variability is an essential feature of the metabolism-cognition relationship.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- The neurovascular coupling basis of cognitive impairment in patients with H-type hypertension: a cross-modal study using resting-state fMRI and arterial spin labeling.Frontiers in medicine · 2026Article
- Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease.Frontiers in neuroscience · 2026Review
- Intermittent fasting and neuroprotection in Alzheimer's disease: metabolic mechanisms, cellular signaling, and brain-peripheral crosstalk.Frontiers in nutrition · 2026Review
- NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Systemic TGF-β1 reduction contributes to neuronal GLUT4 trafficking impairment in acute hepatic encephalopathy.Frontiers in molecular neuroscience · 2026Article
- Dysregulated hippocampal fatty acid metabolism following intermittent hypoxemia-induced neonatal brain injury is rescued by treatment with acetate.Nature communications · 2025Article
- Review
- ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration.Neurochemical research · 2025Review
- Brain and muscle chemistry in myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and long COVID: a 7T magnetic resonance spectroscopy study.Molecular psychiatry · 2025Article
Corrections and comments
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Authors and funding
26 authors at 20 institutions in 8 countries.
Caroline D RaeSchool of Psychology, The University of New South Wales, NSW 2052 & Neuroscience Research Australia, Randwick, New South Wales, Australia.ORCID 0000-0003-0673-8084
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Karin BorgesSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, QLD, Australia.ORCID 0000-0001-7448-0770
Gerald DienelDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Carlos Manlio Díaz-GarcíaDepartment of Biochemistry and Molecular Biology, Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-4352-2496
Starlette R DouglassBehavioral Neuroscience, University at Albany, Albany, New York, USA.ORCID 0000-0001-8520-1765
Kelly DrewCenter for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
João M N DuarteDepartment of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, & Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.ORCID 0000-0001-5984-1574
Jordi DuranInstitut Químic de Sarrià (IQS), Universitat Ramon Llull (URL), Barcelona, Spain.
Oliver KannInstitute of Physiology and Pathophysiology, University of Heidelberg, D-69120; Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-4365-8067
Tibor KristianVeterans Affairs Maryland Health Center System, Baltimore, Maryland, USA.
Dasfne Lee-LiuFacultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Región Metropolitana, Chile.ORCID 0000-0003-1449-4104
Britta E LindquistDepartment of Neurology, Division of Neurocritical Care, Gladstone Institute of Neurological Disease, University of California at San Francisco, San Francisco, California, USA.ORCID 0000-0002-7913-9034
Ewan C McNayBehavioral Neuroscience, University at Albany, Albany, New York, USA.ORCID 0000-0002-4476-5051
Michael B RobinsonDepartments of Pediatrics and System Pharmacology & Translational Therapeutics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-0162-2218
Douglas L RothmanMagnetic Resonance Research Center and Departments of Radiology and Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-9321-4195
Benjamin D RowlandsSchool of Chemistry, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-2782-3184
Timothy A RyanDepartment of Biochemistry, Weill Cornell Medicine, New York, New York, USA.
Joseph ScafidiDepartment of Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Susanna ScafidiAnesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1229-8778
C William ShuttleworthDepartment of Neurosciences, University of New Mexico School of Medicine Albuquerque, Albuquerque, New Mexico, USA.ORCID 0000-0002-0237-4888
Raymond A SwansonDepartment of Neurology, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.ORCID 0000-0002-3664-5359
Gökhan UrukDepartment of Neurology, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
Nina VardjanLaboratory of Cell Engineering, Celica Biomedical, Ljubljana, Slovenia.
Robert ZorecLaboratory of Cell Engineering, Celica Biomedical, Ljubljana, Slovenia.
Mary C McKennaDepartment of Pediatrics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5236-3853
San Francisco VA Medical Center · USUniversity at Albany, State University of New York · USUniversity of Ljubljana · SIUniversity of Maryland, Baltimore · USUniversity of New Mexico · USChildren's Hospital of Philadelphia · USCornell University · USGladstone Institutes · USHeidelberg University · DEInstitute for Bioengineering of Catalonia · ESJohns Hopkins University · USKennedy Krieger Institute · USLund University · SESan Sebastián University · CLThe University of Queensland · AUThe University of Sydney · AUUniversity of Alaska Fairbanks · USUniversity of Oklahoma Health Sciences Center · USUniversity of Pennsylvania · USUNSW Sydney · AU
Funding
University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7MVisualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Veronica Galvan, William Edmund Sonntag · 2019 to 2026
$17.8MProject IV- Cerebellar Function After Hypoxia-Ischemia and Precipitating InflammationP01HD085928 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI MCKENNA, MARY C · 2016 to 2020
$6.3MPhysiology of Single Synaptic CNS TerminalsR37NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2016 to 2022
$3.5MSpreading Depolarizations and Neuronal VulnerabilityR01NS106901 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Claude W Shuttleworth · 2018 to 2026
$2.5MAstroglial Glutamate Transporters, Calcium, and MitochondriaR01NS106693 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBINSON, MICHAEL BYRNE · 2018 to 2021
$2.0MMetabolic Vulnerability of Synapses in Neurodegenerative DiseaseR01NS117139 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2020 to 2024
$2.0MUsing NAD+ precursor for treatment of global cerebral ischemiaR01NS119275 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KRISTIAN, TIBOR · 2021 to 2025
$1.9MBioenergetic Failure Underlies Cerebral Dysmaturity After Perinatal Brain InjuryR01NS099461 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCAFIDI, JOSEPH · 2017 to 2021
$1.9MAberrant Glycogen Modulates Cerebral Glucose Metabolism in Aging and Alzheimer's DiseaseR01AG066653 · NIA · UNIVERSITY OF KENTUCKY · PI SUN, RAMON C. · 2020 to 2024
$1.9MCoordination of fatty acid metabolism following neonatal brain injury from preterm birthR01NS125653 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Joseph Scafidi, Susanna Scafidi · 2022 to 2026
$1.9MMechanisms of metabolic adaptation after traumatic brain injuryR01NS111230 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SCAFIDI, SUSANNA · 2019 to 2023
$1.8MBLRD VA I01 BX004895International Society for Cerebral Blood Flow and MetabolismInternational Society for Neurochemistry ISN-CC Funding for a small conferenceNIA NIH HHS R01 AG066653NIA NIH HHS R13 AG067693NICHD NIH HHS P01 HD085928NIGMS NIH HHS P20 GM109089NIGMS NIH HHS P20 GM125528NINDS NIH HHS R01 NS070280NINDS NIH HHS R01 NS099461NINDS NIH HHS R01 NS106693NINDS NIH HHS R01 NS106901NINDS NIH HHS R01 NS110808NINDS NIH HHS R01 NS111230NINDS NIH HHS R01 NS117139NINDS NIH HHS R01 NS119275NINDS NIH HHS R01 NS125653NINDS NIH HHS R37 NS036942
Abstract
Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD
Indexed as
BrainEnergy MetabolismAnimalsHumansacetateaerobic glycolysisGLUT4insulinnoradrenaline
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