Evidence map›Paper›PMID 38183279›Full record

ArticleEuropean stroke journal2024

Functional outcome improvement from 3 to 12 months after intracerebral hemorrhage.

Andrea Morotti, Jawed Nawabi, Andrea Pilotto, Maddalena Toffali, Giorgio Busto, Federico Mazzacane, Anna Cavallini, Michele Laudisi, Luana Gentile, Maria Maddalena Viola and 10 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Mapping the modified rankin scale (mRS) onto the assessment of quality of life (AQoL) utilities.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 2 countries.

Andrea MorottiDepartment of Continuity of Care and Frailty, Neurology Unit, ASST-Spedali Civili, Brescia, Italy.ORCID 0000-0002-6558-1155
Jawed NawabiDepartment of Neuroradiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin Institute of Health, Berlin, Germany.
Andrea PilottoDepartment of Continuity of Care and Frailty, Neurology Unit, ASST-Spedali Civili, Brescia, Italy.
Maddalena ToffaliDepartment of Continuity of Care and Frailty, Neurology Unit, ASST-Spedali Civili, Brescia, Italy.
Giorgio BustoDepartment of Experimental and Clinical Biomedical Sciences, Neuroradiology Unit, University of Firenze, AOU Careggi, Firenze, Italy.
Federico MazzacaneU.C. Malattie Cerebrovascolari e Stroke Unit, IRCCS Fondazione Mondino, Pavia, Italia.
Anna CavalliniU.C. Malattie Cerebrovascolari e Stroke Unit, IRCCS Fondazione Mondino, Pavia, Italia.ORCID 0000-0002-5227-1502
Michele LaudisiClinica Neurologica, Dipartimento di Scienze Biomediche e Chirurgico Specialistiche, Università degli studi di Ferrara, Ospedale Universitario S. Anna, Ferrara, Italia.
Luana GentileIRCCS Istituto delle Scienze Neurologiche di Bologna,UOC Neurologia e Rete Stroke Metropolitana, Ospedale Maggiore, Bologna, Italia.
Maria Maddalena ViolaIRCCS Istituto delle Scienze Neurologiche di Bologna,UOC Neurologia e Rete Stroke Metropolitana, Ospedale Maggiore, Bologna, Italia.
Frieder SchlunkDepartment of Neuroradiology, Medical Centre, University of Freiburg, Freiburg, Germany.
Diletta BartoliniCardiovascular and Emergency Medicine, Stroke Unit, University of Perugia/Azienda Ospedaliera Santa Maria Della Misericordia, Perugia, Italy.
Maurizio PaciaroniCardiovascular and Emergency Medicine, Stroke Unit, University of Perugia/Azienda Ospedaliera Santa Maria Della Misericordia, Perugia, Italy.ORCID 0000-0002-5483-8795
Mauro MagoniStroke Unit, Neurologia Vascolare, ASST Spedali Civili di Brescia, Brescia, Italy.
Chiara BassiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Luigi SimonettiIRCCS Istituto delle Scienze Neurologiche di Bologna, Neuroradiology Unit, Maggiore Hospital, Bologna, Italy.
Enrico FainardiDepartment of Experimental and Clinical Biomedical Sciences, Neuroradiology Unit, University of Firenze, AOU Careggi, Firenze, Italy.ORCID 0000-0003-0477-724X
Ilaria CasettaClinica Neurologica, Dipartimento di Scienze Biomediche e Chirurgico Specialistiche, Università degli studi di Ferrara, Ospedale Universitario S. Anna, Ferrara, Italia.ORCID 0000-0003-4099-8875
Andrea ZiniIRCCS Istituto delle Scienze Neurologiche di Bologna,UOC Neurologia e Rete Stroke Metropolitana, Ospedale Maggiore, Bologna, Italia.
Alessandro PadovaniDepartment of Continuity of Care and Frailty, Neurology Unit, ASST-Spedali Civili, Brescia, Italy.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITOspedale Maggiore · ITAzienda Ospedaliero-Universitaria Careggi · ITFondazione Istituto Neurologico Nazionale Casimiro Mondino · ITIstituto delle Scienze Neurologiche di Bologna · ITUniversity of Ferrara · ITUniversity of Perugia · ITHumboldt-Universität zu Berlin · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMost intracerebral hemorrhage (ICH) trials assessed outcome at 3 months but the recovery trajectory of ICH survivors may continue up to 1 year after the index event. We aimed to describe the predictors of functional outcome improvement from 3 to 12 months after ICH. MATERIALS AND

methodsRetrospective analysis of patients admitted to six European Stroke Centers for supratentorial ICH. Functional outcome was measured with the modified Rankin Scale (mRS) at 3 and 12 months. Predictors of functional outcome improvement were explored with binary logistic regression.

resultsWe included 703 patients, of whom 245 (34.9%) died within 3 months. Among survivors, 131 (28.6%) had an mRS improvement, 78 (17.0%) had a worse mRS and 249 (54.4%) had a stable functional status at 12 months. Older age and the presence of baseline disability (defined as pre-stroke mRS > 1), were associated with lower odds of functional outcome improvement (Odds Ratio (OR) 0.98 per year increase, 95% Confidence Interval (CI) 0.96-1.00, DISCUSSION AND

conclusionLong term recovery is common after ICH and associated with age, baseline functional status, mRS at 3 months and hematoma location. Our findings might inform future trials and improve long-term prognostication in clinical practice.

Indexed as

Cerebral HemorrhageRecovery of FunctionAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeimprovementIntracerebral hemorrhagemodified Rankin Scaleoutcomerecovery

Identifiers

PMID38183279
PMCPMC11318429
OpenAlexW4390637191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.