Evidence map›Paper›PMID 38182911›Full record

ArticleArchives of toxicology2024

Hepatic glucuronidation of tetrabromobisphenol A and tetrachlorobisphenol A: interspecies differences in humans and laboratory animals and responsible UDP-glucuronosyltransferase isoforms in humans.

Nobumitsu Hanioka, Takashi Isobe, Keita Saito, Kenjiro Nagaoka, Yoko Mori, Hideto Jinno, Susumu Ohkawara, Toshiko Tanaka-Kagawa

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Nobumitsu HaniokaDepartment of Health Pharmacy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, 245-0066, Japan. nhanioka@hamayaku.ac.jp.ORCID 0000-0003-4121-119X
Takashi IsobeDepartment of Health Pharmacy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, 245-0066, Japan.
Keita SaitoSchool of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Naka-ku, Okayama, 703-8516, Japan.
Kenjiro NagaokaCollege of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, 790-8578, Japan.
Yoko MoriHealth and Environmental Risk Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, 305-8506, Japan.
Hideto JinnoFaculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan.
Susumu OhkawaraDepartment of Health Pharmacy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, 245-0066, Japan.
Toshiko Tanaka-KagawaDepartment of Health Pharmacy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, 245-0066, Japan.
Yokohama University of Pharmacy · JPMatsuyama University · JPMeijo University · JPNational Institute for Environmental Studies · JPShujitsu University · JP

Funding

Japan Society for the Promotion of Science 23K09659
6 · The paper itself

Abstract

Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), bisphenol A (BPA) analogs, are endocrine-disrupting chemicals predominantly metabolized into glucuronides by UDP-glucuronosyltransferase (UGT) enzymes in humans and rats. In the present study, TBBPA and TCBPA glucuronidation by the liver microsomes of humans and laboratory animals (monkeys, dogs, minipigs, rats, mice, and hamsters) and recombinant human hepatic UGTs (10 isoforms) were examined. TBBPA glucuronidation by the liver microsomes followed the Michaelis-Menten model kinetics in humans, rats, and hamsters and the biphasic model in monkeys, dogs, minipigs, and mice. The CL

Indexed as

ChlorophenolsLiverMicrosomes, LiverPolybrominated BiphenylsAnimalsAnimals, LaboratoryDogsGlucuronidesGlucuronosyltransferaseHaplorhiniHumansKineticsMiceProtein IsoformsRatsSwineChlorophenolsGlucuronidesGlucuronosyltransferasePolybrominated BiphenylsProtein Isoformstetrabromobisphenol AtetrachlorodianUridine DiphosphateGlucuronidationInterspecies differenceLiverTetrabromobisphenol A (TBBPA)Tetrachlorobisphenol A (TCBPA)UDP-glucuronosyltransferase (UGT)

Identifiers

PMID38182911
OpenAlexW4390619253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.