ArticleNature neuroscience2024
Women's neuroplasticity during gestation, childbirth and postpartum.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Multidimensional psychological and neurophysiological effects of moderate- and low-intensity exercise on pregnant women: an integrative systematic review and Bayesian framework network meta-analysis.Archives of women's mental health · 2026Pooled it
- Translational interdisciplinary research on human chorionic gonadotropin's enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders.Frontiers in psychiatry · 2025Pooled it
- Mindfulness-based stress reduction intervention during pregnancy changes maternal brain.Scientific reports · 2025Trial
- Puberty, pregnancy, and menopause show shared and distinct structural changes across the lifespan.Nature communications · 2026Article
- Examining dynamic changes in prefrontal connectivity and internalizing symptoms during the first and third trimesters of pregnancy.Journal of neuroendocrinology · 2026Article
- Bonding before birth: Maternal-fetal attachment and maternal cortical connectivity in late pregnancy.Journal of neuroendocrinology · 2026Article
- Triple Network Neuroplasticity and Perinatal Mood Symptoms from Preconception to Postpartum: A Pilot Study.Journal of clinical medicine · 2026Article
- Postpartum maternal bonding problems relate to aberrant neural processing of infant emotions: Results of an adapted fMRI emotional GoNoGo task.Translational psychiatry · 2026Article
- The social circumstances of the maternal experience and its biobehavioral associations, in rhesus macaques (Macaca mulatta).Animal reproduction science · 2026Article
- GABAergic Neuroactive Steroids and Network States: Relevance to Peripartum Depression.Biological psychiatry · 2026Review
- Review
- The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.bioRxiv : the preprint server for biology · 2026Article
- Single-cell map of the female brain across reproductive transitions.bioRxiv : the preprint server for biology · 2026Article
- Progesterone-associated adjustments in brain structure during menstruation and the periovulatory phase-an MRI study.EBioMedicine · 2026Article
- The effects of a second pregnancy on women's brain structure and function.Nature communications · 2026Article
- Intrinsic resting-state connectivity and personal meaning across the transition to fatherhood.Emotion (Washington, D.C.) · 2026Article
- Appetitive maternal behavior in mice is resistant to perinatal chronic variable stress and perinatal chronic corticosterone treatment.Hormones and behavior · 2026Article
- Inter- and intra-individual differences in brain sex map to neuroendocrine profiles.bioRxiv : the preprint server for biology · 2025Article
- Reproductive experience influences the effects of Lactocaseibacillus rhamnosus HN001 on gut microbiota and hippocampal plasticity in female rats.Journal of neuroendocrinology · 2025Article
- Report: Workshop on maternal mental health, February 11-12, 2024, cosponsored by the American College of Obstetricians and Gynecologists.Pregnancy (Hoboken, N.J.) · 2025Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Pregnancy is a unique neuroplastic period in adult life. This longitudinal study tracked brain cortical changes during the peripartum period and explored how the type of childbirth affects these changes. We collected neuroanatomic, obstetric and neuropsychological data from 110 first-time mothers during late pregnancy and early postpartum, as well as from 34 nulliparous women evaluated at similar time points. During late pregnancy, mothers showed lower cortical volume than controls across all functional networks. These cortical differences attenuated in the early postpartum session. Default mode and frontoparietal networks showed below-expected volume increases during peripartum, suggesting that their reductions may persist longer. Results also pointed to different cortical trajectories in mothers who delivered by scheduled C-section. The main findings were replicated in an independent sample of 29 mothers and 24 nulliparous women. These data suggest a dynamic trajectory of cortical decreases during pregnancy that attenuates in the postpartum period, at a different rate depending on the brain network and childbirth type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.