Evidence map›Paper›PMID 38182820›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2024

Ruthenium(II) complex with 2-mercaptothiazoline ligand induces selective cytotoxicity involving DNA damage and apoptosis in melanoma cells.

Matheus Reis Santos de Melo, Arthur Barcelos Ribeiro, Gabriela Fernandes, Iara Silva Squarisi, Marcela de Melo Junqueira, Alzir Azevedo Batista, Monize Martins da Silva, Denise Crispim Tavares

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Matheus Reis Santos de MeloLaboratory of Mutagenesis, University of Franca, Franca, São Paulo, 14404-600, Brazil. matheusreismelo@outlook.com.ORCID 0000-0001-5475-2492
Arthur Barcelos RibeiroLaboratory of Mutagenesis, University of Franca, Franca, São Paulo, 14404-600, Brazil.ORCID 0000-0002-4056-9571
Gabriela FernandesLaboratory of Mutagenesis, University of Franca, Franca, São Paulo, 14404-600, Brazil.ORCID 0000-0003-4796-386X
Iara Silva SquarisiLaboratory of Mutagenesis, University of Franca, Franca, São Paulo, 14404-600, Brazil.ORCID 0000-0003-1962-3702
Marcela de Melo JunqueiraLaboratory of Mutagenesis, University of Franca, Franca, São Paulo, 14404-600, Brazil.ORCID 0000-0002-4636-4446
Alzir Azevedo BatistaDepartment of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, 13565-905, Brazil.ORCID 0000-0002-4671-2754
Monize Martins da SilvaDepartment of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, 13565-905, Brazil.
Denise Crispim TavaresLaboratory of Mutagenesis, University of Franca, Franca, São Paulo, 14404-600, Brazil. denisecrispim2001@yahoo.com.ORCID 0000-0003-4646-5914
Universidade de Franca · BRUniversidade Federal de São Carlos · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.4810118/2020-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/15850-0
6 · The paper itself

Abstract

Melanoma is the most aggressive and lethal type of skin cancer due to its characteristics such as high metastatic potential and low response rate to existing treatment modalities. In this way, new drug prototypes are being studied to solve the problem of treating patients with melanoma. Among these, ruthenium-based metallopharmaceuticals may be promising alternatives due to their antitumor characteristics and low systemic toxicity. In this context, the present study evaluated the antineoplastic effect of the ruthenium complex [Ru(mtz)(dppe)

Indexed as

Antineoplastic AgentsCoordination ComplexesMelanomaRutheniumThiazolidinesAnimalsApoptosisCell Line, TumorDNA DamageHumansLigandsMice2-mercaptothiazolineAntineoplastic AgentsCoordination ComplexesLigandsRutheniumThiazolidinesCaspase-3CytotoxicityThiazolineTopoisomeraseγH2AX

Identifiers

PMID38182820
OpenAlexW4390618453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.