Evidence map›Paper›PMID 38182727›Full record

ArticleCommunications biology2024

Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma.

Zhiwei Liu, Yang Luo, Samuel Kirimunda, Murielle Verboom, Olusegun O Onabajo, Mateus H Gouveia, Martin D Ogwang, Patrick Kerchan, Steven J Reynolds, Constance N Tenge and 39 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors at 20 institutions in 8 countries.

Zhiwei Liu *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-0136-651X
Yang Luo *Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID 0000-0001-7385-6166
Samuel KirimundaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Murielle VerboomInstitute of Transfusion Medicine and Transplant Engineering, Hanover, Germany.
Olusegun O OnabajoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-6342-2380
Mateus H GouveiaCenter for Research on Genomics & Global Health, NHGRI, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6711-5265
Martin D OgwangSt. Mary's Hospital, Lacor, Gulu, Uganda.
Patrick KerchanEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Steven J ReynoldsDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Constance N TengeEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Pamela A WereEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Robert T KuremuEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Walter N WekesaEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Nestory MasaluBugando Medical Center, Mwanza, Tanzania.
Esther KawiraEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Tobias KinyeraSt. Mary's Hospital, Lacor, Gulu, Uganda.
Isaac OtimSt. Mary's Hospital, Lacor, Gulu, Uganda.
Ismail D LegasonEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.ORCID 0000-0002-6118-542X
Hadijah NabalendeSt. Mary's Hospital, Lacor, Gulu, Uganda.
Herry DhudhaEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Leona W AyersDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Kishor BhatiaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
James J GoedertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Nathan ColeCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Wen LuoCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Jia LiuCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Michelle ManningCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Belynda HicksCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0001-8014-4888
Ludmila Prokunina-OlssonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-9622-2091
George ChagalukaDepartments of Pediatrics and Surgery, Kamuzu University of Health Sciences (formerly College of Medicine), University of Malawi, Blantyre, Malawi.
W Thomas JohnstonEpidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
Nora MutalimaEpidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
Eric BorgsteinDepartments of Pediatrics and Surgery, Kamuzu University of Health Sciences (formerly College of Medicine), University of Malawi, Blantyre, Malawi.
George N LiombaDepartments of Pediatrics and Surgery, Kamuzu University of Health Sciences (formerly College of Medicine), University of Malawi, Blantyre, Malawi.
Steve KamizaDepartments of Pediatrics and Surgery, Kamuzu University of Health Sciences (formerly College of Medicine), University of Malawi, Blantyre, Malawi.
Nyengo MkandawireDepartments of Pediatrics and Surgery, Kamuzu University of Health Sciences (formerly College of Medicine), University of Malawi, Blantyre, Malawi.
Collins MitamboNational Health Sciences Research Committee, Research Department, Ministry of Health, Lilongwe, Malawi.
Elizabeth M MolyneuxDepartments of Pediatrics and Surgery, Kamuzu University of Health Sciences (formerly College of Medicine), University of Malawi, Blantyre, Malawi.
Robert NewtonEpidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.ORCID 0000-0001-6715-9153
Ann W HsingStanford Cancer Institute, Stanford University, Stanford, CA, USA.
James E MensahUniversity of Ghana Medical School, Accra, Ghana.
Anthony A AdjeiUniversity of Ghana Medical School, Accra, Ghana.
Amy HutchinsonCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-2692-2180
Meredith YeagerCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0003-3871-2225
Rainer BlasczykInstitute of Transfusion Medicine and Transplant Engineering, Hanover, Germany.ORCID 0000-0003-3875-3190
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-2324-3393
Soumya RaychaudhuriCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1901-8265
Sam M MbulaiteyeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. mbulaits@mail.nih.gov.ORCID 0000-0002-8273-9831
Frederick National Laboratory for Cancer Research · USNational Cancer Institute · USUniversity of Malawi · MWSt. Mary's Hospital Lacor · UGMoi University · KEAfrican Field Epidemiology Network · UGBroad Institute · USImmungenetics (Germany) · DEKuluva Hospital · UGNational Institutes of Health · USUniversity of Ghana · GHUniversity of York · GBAMPATH · KEBugando Medical Centre · TZMakerere University · UGMinistry of Health · MWRagon Institute of MGH, MIT and Harvard · USStanford University · USThe Ohio State University · USUniversity of Oxford · GB

Funding

International Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5M
Effects of genetic polymorphism in MHC, KIR, and related loci on human diseaseZIABC010791 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$18.2M
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4M
Medical Research Council MC_UU_00033/1NCI NIH HHS HHSN261201100007INCI NIH HHS HHSN261201100063CNHLBI NIH HHS HHSN261201100007CNIAMS NIH HHS R01 AR063759
6 · The paper itself

Abstract

Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human leukocyte antigen (HLA) polymorphisms, which regulate immune response, are associated with BL has not been well investigated, which limits our understanding of BL etiology. Here we investigate this association among 4,645 children aged 0-15 years, 800 with BL, enrolled in Uganda, Tanzania, Kenya, and Malawi. HLA alleles are imputed with accuracy >90% for HLA class I and 85-89% for class II alleles. BL risk is elevated with HLA-DQA1*04:01 (adjusted odds ratio [OR] = 1.61, 95% confidence interval [CI] = 1.32-1.97, P = 3.71 × 10

Indexed as

Burkitt LymphomaEpstein-Barr Virus InfectionsChildHerpesvirus 4, HumanHLA-DQ alpha-ChainsHumansHLA-DQA1 antigenHLA-DQ alpha-Chains

Identifiers

PMID38182727
PMCPMC10770398
OpenAlexW4390603622

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.