Evidence map›Paper›PMID 38182718›Full record

ArticleScientific reports2024

Blood and MRI biomarkers of mild traumatic brain injury in non-concussed collegiate football players.

Eunhan Cho, Joshua Granger, Bailey Theall, Nathan Lemoine, Derek Calvert, Jack Marucci, Shelly Mullenix, Hollis O'Neal, Tomas Jacome, Brian A Irving and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eunhan ChoSchool of Kinesiology, Louisiana State University, Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Joshua GrangerSchool of Kinesiology, Louisiana State University, Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Bailey TheallSchool of Kinesiology, Louisiana State University, Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Nathan LemoineLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Derek CalvertLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Jack MarucciLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Shelly MullenixLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Hollis O'NealLouisiana State University Health Sciences Center, Baton Rouge, LA, 70803, USA.
Tomas JacomeOur Lady of the Lake, Baton Rouge, LA, 70810, USA.
Brian A IrvingSchool of Kinesiology, Louisiana State University, Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Neil M JohannsenSchool of Kinesiology, Louisiana State University, Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Owen CarmichaelPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Guillaume SpielmannSchool of Kinesiology, Louisiana State University, Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA. gspielmann@lsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Football has one of the highest incidence rates of mild traumatic brain injury (mTBI) among contact sports; however, the effects of repeated sub-concussive head impacts on brain structure and function remain under-studied. We assessed the association between biomarkers of mTBI and structural and functional MRI scans over an entire season among non-concussed NCAA Division I linemen and non-linemen. Concentrations of S100B, GFAP, BDNF, NFL, and NSE were assessed in 48 collegiate football players (32 linemen; 16 non-linemen) before the start of pre-season training (pre-camp), at the end of pre-season training (pre-season), and at the end of the competitive season (post-season). Changes in brain structure and function were assessed in a sub-sample of 11 linemen and 6 non-linemen using structural and functional MRI during the execution of Stroop and attention network tasks. S100B, GFAP and BDNF concentrations were increased at post-season compared to pre-camp in linemen. White matter hyperintensities increased in linemen during pre-season camp training compared to pre-camp. This study showed that the effects of repeated head impacts are detectable in the blood of elite level non-concussed collegiate football players exposed to low-moderate impacts to the heads, which correlated with some neurological outcomes without translating to clinically-relevant changes in brain anatomy or function.

Indexed as

Brain ConcussionFootballBiomarkersBrain-Derived Neurotrophic FactorHumansMagnetic Resonance ImagingBiomarkersBrain-Derived Neurotrophic Factor

Identifiers

PMID38182718
PMCPMC10770029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.