ArticleNature communications2024
Functional host-specific adaptation of the intestinal microbiome in hominids.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Partner fidelity, not geography, drives co-diversification of gut microbiota with hominids.Biology letters · 2025Pooled it
- Stability in flexibility: Shifting alliances stabilize the symbioses of marine animals over 150 million years.Science advances · 2026Article
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Stop codon reassignment to tryptophan in members of the bacterial phylumMicrobial genomics · 2026Article
- Evolutionary Genomics of Human Gut Bacteria: Ecological Plasticity Across the Mutualism-Pathogenicity Spectrum.International journal of molecular sciences · 2026Review
- Genomic-microbial coevolution in human development: chromosome 2 fusion, and human accelerated regions.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Cross-species fecal microbiota transplantation alters the carbohydrate metabolic phenotype: insights from Gansu zokor (Eospalax cansus).BMC veterinary research · 2026Article
- Post-defecation exposure alters gut microbiota of forest musk deer with implications for conservation metagenomics.Applied microbiology and biotechnology · 2026Article
- Accumulation of antimicrobial resistance genes in wild chimpanzees.The ISME journal · 2026Article
- How "pro" are probiotics for wildlife species? Novel data, lack of evidence, and future directions.ISME communications · 2026Article
- Loss of microbial diversity from human-microbe coevolution: immune, epigenetic, and enteric nervous system mechanisms linking dysbiosis to neuropsychiatric and neurodegenerative diseases.Frontiers in neuroscience · 2026Review
- Genome-resolved analysis of colonization factor repertoires reveals ecological stratification in cervid gut microbiomes.Frontiers in microbiology · 2026Article
- From forest to farm: the impact of a broad spectrum of lifestyles on the porcine gut microbiota.Current research in microbial sciences · 2026Article
- A Hadza-enrichedGut microbes reports · 2026Article
- Genomic and functional co-diversification imprint African Hominidae microbiomes to signal dietary and lifestyle adaptations.Gut microbes · 2025Article
- Comprehensive metagenomic analysis of the giant panda's oral microbiome reveals distinct taxonomic and functional characteristics.Animal microbiome · 2025Article
- Industrialization drives convergent microbial and physiological shifts in the human metaorganism.bioRxiv : the preprint server for biology · 2025Article
- Evolution of gut microbiota across honeybee species revealed by comparative metagenomics.Nature communications · 2025Article
- A comprehensive atlas of the bonobo gut bacteriome and its associated host and exposome factors.Cell reports · 2025Article
- Structural and functional characterization of a porcine intestinal microbial ecosystem developed in vitro.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
18 authors at 10 institutions in 7 countries.
Funding
Abstract
Fine-scale knowledge of the changes in composition and function of the human gut microbiome compared that of our closest relatives is critical for understanding the evolutionary processes underlying its developmental trajectory. To infer taxonomic and functional changes in the gut microbiome across hominids at different timescales, we perform high-resolution metagenomic-based analyzes of the fecal microbiome from over two hundred samples including diverse human populations, as well as wild-living chimpanzees, bonobos, and gorillas. We find human-associated taxa depleted within non-human apes and patterns of host-specific gut microbiota, suggesting the widespread acquisition of novel microbial clades along the evolutionary divergence of hosts. In contrast, we reveal multiple lines of evidence for a pervasive loss of diversity in human populations in correlation with a high Human Development Index, including evolutionarily conserved clades. Similarly, patterns of co-phylogeny between microbes and hosts are found to be disrupted in humans. Together with identifying individual microbial taxa and functional adaptations that correlate to host phylogeny, these findings offer insights into specific candidates playing a role in the diverging trajectories of the gut microbiome of hominids. We find that repeated horizontal gene transfer and gene loss, as well as the adaptation to transient microaerobic conditions appear to have played a role in the evolution of the human gut microbiome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.