Evidence map›Paper›PMID 38182585›Full record

ArticleNature communications2024

Secreted IgM modulates IL-10 expression in B cells.

Shannon Eileen McGettigan, Lazaro Emilio Aira, Gaurav Kumar, Romain Ballet, Eugene C Butcher, Nicole Baumgarth, Gudrun F Debes

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Regulatory B Cells in Tumor Microenvironment.Current issues in molecular biology · 2026
    Review
  9. Article
  10. Dynamics of IgM and IgA Antibody Response Profile AgainstInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shannon Eileen McGettiganDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA.ORCID 0000-0003-1421-0511
Lazaro Emilio AiraDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Gaurav KumarDepartment of Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Romain BalletPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.ORCID 0000-0002-5802-9346
Eugene C ButcherPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.ORCID 0000-0001-8786-7907
Nicole BaumgarthCenter for Immunology and Infectious Diseases, Dept. Pathology, Microbiology & Immunology, University of California Davis, Davis, CA, USA.ORCID 0000-0002-2891-4483
Gudrun F DebesDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA. Gudrun.debes@jefferson.edu.ORCID 0000-0003-4208-7362
Thomas Jefferson University · USPalo Alto Veterans Institute for Research · USJohns Hopkins University · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Claudio Guillermo Giraudo · 1995 to 2026
$94.8M
Progenitor Cells for High Endothelium in the Immune ResponseR01AI130471 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI EUGENE C BUTCHER · 2017 to 2026
$5.0M
Intestinal Lymphocyte TraffickingR01AI047822 · NIAID · STANFORD UNIVERSITY · PI EUGENE C BUTCHER · 2001 to 2026
$4.7M
Intestinal Lymphocyte TraffickingR37AI047822 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI BUTCHER, EUGENE C · 2011 to 2020
$3.5M
B-1 cells, IgM and Protective Humoral Immunity to InfluenzaR01AI148652 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMGARTH, NICOLE · 2019 to 2023
$2.4M
Migration and function of skin B cellsR01AR067751 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI DEBES, GUDRUN PHILOMENA · 2016 to 2020
$1.7M
Migration and function of cutaneous B cellsR01AI127389 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI DEBES, GUDRUN PHILOMENA · 2017 to 2021
$1.6M
Training grant on Vaccines and Immunotherapies for Infectious Diseases and CancerT32AI134646 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SCHNELL, MATTHIAS JOHANNES, SIGAL, LUIS J · 2018 to 2022
$1.1M
Regulation of antibody production by B-1 cellsR21AI151995 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMGARTH, NICOLE · 2020 to 2021
$432k
The role of IgM in the regulation of skin inflammationR56AI165750 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI DEBES, GUDRUN PHILOMENA · 2022 to 2022
$285k
CCR9 AND TECK IN INTESTINAL LYMPHOCYTE TRAFFICKINGR21AI047822 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BUTCHER, EUGENE C · 2000 to 2000
$258k
NCI NIH HHS P30 CA056036NIAID NIH HHS R01 AI047822NIAID NIH HHS R01 AI127389NIAID NIH HHS R01 AI130471NIAID NIH HHS R01 AI148652NIAID NIH HHS R21 AI047822NIAID NIH HHS R21 AI151995NIAID NIH HHS R37 AI047822NIAID NIH HHS R56 AI165750NIAID NIH HHS T32 AI134646NIAMS NIH HHS R01 AR067751
6 · The paper itself

Abstract

IL-10

Indexed as

B-Lymphocyte SubsetsImmunoglobulin MInterleukin-10AnimalsB-LymphocytesHomeostasisMiceImmunoglobulin MInterleukin-10

Identifiers

PMID38182585
PMCPMC10773282
OpenAlexW4390619377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.