Evidence map›Paper›PMID 38182527›Full record

ReviewPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2024

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.

Takao Ohtsuka, Carlos Fernandez-Del Castillo, Toru Furukawa, Susumu Hijioka, Jin-Young Jang, Anne Marie Lennon, Yoshihiro Miyasaka, Eizaburo Ohno, Roberto Salvia, Christopher L Wolfgang and 1 more

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 252 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07014709 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of GLP-1 Receptor Agonists on Patients With Intraductal Papillary Mucinous Neoplasms: A Retrospective Multicentric Cohort Study

TypeobservationalSponsorHôpital FribourgeoisRan2025 to 2026Enrolled30ConditionsIPMN, IPMN, Pancreatic, GLP-1, Intraductal Papillary Mucinous Neoplasm of PancreasArmsGLP1 receptor agonist
NCT07535125 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

IPEX Study: Pancreatic Exocrine Insufficiency as a Functional Marker of Disease Progression in Patients With IPMN Under Surveillance

TypeobservationalSponsorA.O.U. Città della Salute e della ScienzaRan2026 to 2027Enrolled600ConditionsIntraductal Papillary Mucinous Neoplasms, Pancreatic Exocrine Insufficiency
3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  19. High grade PanIN is associated with malignancy risk in IPMN patients.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2026
    Article
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192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Takao OhtsukaDepartment of Digestive Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. Electronic address: takao-o@kufm.kagoshima-u.ac.jp.
Carlos Fernandez-Del CastilloDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: cfernandez@mgh.harvard.edu.
Toru FurukawaDepartment of Investigative Pathology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Susumu HijiokaDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Jin-Young JangDivision of Hepatobiliary-Pancreatic Surgery, Departments of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Anne Marie LennonDivision of Gastroenterology and Hepatology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Yoshihiro MiyasakaDepartment of Surgery, Fukuoka University Chikushi Hospital, and Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Eizaburo OhnoDepartment of Gastroenterology and Hepatology, Fujita Health University, Toyoake, Aichi, Japan.
Roberto SalviaDepartment of Surgery, Dentistry, Paediatrics and Gynaecology University of Verona, Verona, Italy.
Christopher L WolfgangDepartment of Surgery, New York University Grossman School of Medicine, USA.
Laura D WoodDepartments of Pathology and Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study group aimed to revise the 2017 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas, and mainly focused on five topics; the revision of high-risk stigmata (HRS) and worrisome features (WF), surveillance of non-resected IPMN, surveillance after resection of IPMN, revision of pathological aspects, and investigation of molecular markers in cyst fluid. A new development from the prior guidelines is that systematic reviews were performed for each one of these topics, and published separately to provide evidence-based recommendations. One of the highlights of these new "evidence-based guidelines" is to propose a new management algorithm, and one major revision is to include into the assessment of HRS and WF the imaging findings from endoscopic ultrasound (EUS) and the results of cytological analysis from EUS-guided fine needle aspiration technique, when this is performed. Another key element of the current guidelines is to clarify whether lifetime surveillance for small IPMNs is required, and recommends two options, "stop surveillance" or "continue surveillance for possible development of concomitant pancreatic ductal adenocarcinoma", for small unchanged BD-IPMN after 5 years surveillance. Several other points are also discussed, including identifying high-risk features for recurrence in patients who underwent resection of non-invasive IPMN with negative surgical margin, summaries of the recent observations in the pathology of IPMN. In addition, the emerging role of cyst fluid markers that can aid in distinguishing IPMN from other pancreatic cysts and identify those IPMNs that harbor high-grade dysplasia or invasive carcinoma is discussed.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic Intraductal NeoplasmsPancreatic NeoplasmsEndosonographyHumansPancreasGuidelinesInternational Association of PancreatologyIntraductal papillary mucinous neoplasmPancreatic cancerSurveillance

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.