ArticleThe Thoracic and cardiovascular surgeon2025
Sex Differences in the Histopathology of Acute Type A Aortic Dissections.
Article in The Thoracic and cardiovascular surgeon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Meta-analysis of the histopathological features of surgically removed aortas classified according to the SCVP and AECVP consensus documents.American heart journal plus : cardiology research and practice · 2026Article
- Sex differences in pain presentation and its association with distal extent in acute type A aortic dissection: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Beyond the tear: the enduring role of aortic pathology in the era of genomic medicine.Open heart · 2026Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough sex-related differences in cardiovascular surgery outcomes have increasingly garnered attention in the past decades, knowledge about sex disparities in the pathophysiology of acute type A aortic dissections (ATAADs) remains sparse. In this study, we evaluate the histopathologic and atherosclerotic lesions in female and male ATAAD patients.
methodsA total of 68 patients were studied: 51 ATAAD patients (mean age: 62.5 ± 10.8 years; 49% women) and 17 control patients (mean age: 63 ± 5.5 years; 53% women). Cardiovascular risk factors were assessed clinically. Intimal and medial histopathological features were systematically evaluated in all.
resultsCompared to the control group, all ATAAD patients showed significantly more elastic fiber pathology, mucoid extracellular matrix accumulation, smooth muscle cell nuclei loss, and overall medial degeneration (
conclusionAll ATAAD patients had a significantly thinner tunica intima and significantly diseased tunica media compared to the control patients. Our results suggest that the severity of medial aortic pathology is not sex specific in ATAAD patients. Intimal differences between females and males could, however, be considered a potential risk factor for the development of an aortic dissection.
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