ArticleCurrent biology : CB2024
The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila.
Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Central complex representations of self-movement are sufficient to compute wind direction in flight.Science advances · 2026Article
- Neural dynamics for working memory and evidence integration during olfactory navigation in Drosophila.Nature communications · 2026Article
- Cell type-agnostic transcriptomic signatures enable uniform comparisons of neural maturation.PLoS biology · 2026Article
- Unexpected Evolutionary Divergence of Tachykinin-Positive Neurons Innervating the Central Complex in Hexapods.The Journal of comparative neurology · 2026Article
- Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization.Development (Cambridge, England) · 2026Article
- Neural dynamics for working memory and evidence integration during olfactory navigation inbioRxiv : the preprint server for biology · 2025Article
- Imp and Chinmo are required for embryonic motor neuron axon and dendrite targeting.Biology open · 2025Article
- Article
- Cell type-specific driver lines targeting theeLife · 2025Article
- Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators ofScience advances · 2025Article
- Cell type-specific driver lines targeting thebioRxiv : the preprint server for biology · 2025Article
- From the Making of a Neural Lineage to the Making of a Tumor: Lessons from the "Simple" Drosophila Brain.Advances in experimental medicine and biology · 2025Review
- Castor is a temporal transcription factor that specifies early born central complex neuron identity.Development (Cambridge, England) · 2024Article
- Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning.Science advances · 2024Article
- Stem cell-specific ecdysone signaling regulates the development of dorsal fan-shaped body neurons and sleep homeostasis.Current biology : CB · 2024Article
- Article
- Addendum: A neural circuit for wind-guided olfactory navigation.Nature communications · 2024Article
- Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning.bioRxiv : the preprint server for biology · 2023Article
- Stem cell-specific ecdysone signaling regulates the development and function of abioRxiv : the preprint server for biology · 2023Article
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8 authors at 2 institutions in 1 country.
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Abstract
Complex behaviors depend on the precise developmental specification of neuronal circuits, but the relationship between genetic programs for neural development, circuit structure, and behavioral output is often unclear. The central complex (CX) is a conserved sensory-motor integration center in insects, which governs many higher-order behaviors and largely derives from a small number of type II neural stem cells (NSCs). Here, we show that Imp, a conserved IGF-II mRNA-binding protein expressed in type II NSCs, plays a role in specifying essential components of CX olfactory navigation circuitry. We show the following: (1) that multiple components of olfactory navigation circuitry arise from type II NSCs. (2) Manipulating Imp expression in type II NSCs alters the number and morphology of many of these circuit elements, with the most potent effects on neurons targeting the ventral layers of the fan-shaped body (FB). (3) Imp regulates the specification of Tachykinin-expressing ventral FB input neurons. (4) Imp is required in type II NSCs for establishing proper morphology of the CX neuropil structures. (5) Loss of Imp in type II NSCs abolishes upwind orientation to attractive odor while leaving locomotion and odor-evoked regulation of movement intact. Taken together, our findings establish that a temporally expressed gene can regulate the expression of a complex behavior by developmentally regulating the specification of multiple circuit components and provides a first step toward a developmental dissection of the CX and its roles in behavior.
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