Evidence map›Paper›PMID 38181505›Full record

ArticleJournal of the American Chemical Society2024

Water inside the Selectivity Filter of a K

Matthew J Ryan, Lujia Gao, Francis I Valiyaveetil, Alexei A Kananenka, Martin T Zanni

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Do selectivity filter carbonyls in KJournal of structural biology: X · 2024
    Article
  11. Article
  12. Article
  13. Unraveling dynamic protein structures by two-dimensional infrared spectra with a pretrained machine learning model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Matthew J RyanDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-1633-9087
Lujia GaoDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239, United States.
Francis I ValiyaveetilDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239, United States.ORCID 0000-0002-3387-8018
Alexei A KananenkaDepartment of Physics and Astronomy, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0001-9422-7203
Martin T ZanniDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0001-7191-9768
Oregon Health & Science University · USUniversity of Wisconsin–Madison · USUniversity of Delaware · US

Funding

A new perspesective on ion conductance and structural dynamics of ion channels using 2D IRR01GM135936 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ZANNI, MARTIN T · 2020 to 2025
$1.7M
PowerEdge XE8640 GPU cluster for molecular dynamics simulations and machine learning computational vibrational spectroscopy of ion channelsR35GM150963 · NIGMS · UNIVERSITY OF DELAWARE · PI Alexei Kananenka · 2023 to 2026
$1.3M
NIGMS NIH HHS R01 GM135936NIGMS NIH HHS R35 GM150963
6 · The paper itself

Abstract

Water inside biological ion channels regulates the key properties of these proteins, such as selectivity, ion conductance, and gating. In this article, we measure the picosecond spectral diffusion of amide I vibrations of an isotope-labeled KcsA potassium channel using two-dimensional infrared (2D IR) spectroscopy. By combining waiting time (100-2000 fs) 2D IR measurements of the KcsA channel including

Identifiers

PMID38181505
PMCPMC10797622
OpenAlexW4390605780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.