ArticleScience immunology2024
Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
15.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 66 citations in OpenAlex.
- Beyond immune suppression: regenerative programs in regulatory T cells.Cell insight · 2026Review
- A two-hit mechanism triggers autoimmune hair loss.Nature · 2026Article
- Shelterin TPP1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells.Aging cell · 2026Article
- Regulatory T cells in the skin: Origin, function, and plasticity.JID innovations : skin science from molecules to population health · 2026Review
- S100 signaling in hair follicle biology: emerging mechanistic insights and therapeutic opportunities.Journal of molecular histology · 2026Review
- The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells.Research square · 2026Article
- Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets.Health science reports · 2026Article
- Targeting the Gut Microbiota with Pro- and Postbiotics: Emerging Strategies against Alopecia.Probiotics and antimicrobial proteins · 2026Review
- A Theoretical Model for the Treatment of Androgenetic Alopecia Using the STEAP3 Protein, and the Genetic Challenges of Treating AGA.Health science reports · 2026Article
- Article
- Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026Article
- Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity.Cell · 2026Article
- Racial and Ethnic Disparities in Persistent Chemotherapy-Induced Alopecia Among Women With Breast Cancer.JAMA network open · 2026Article
- IL-15 in alopecia areata: the immune tolerance mechanistic insights and translational perspectives.Frontiers in medicine · 2026Review
- Engineering immune-competent hair follicle microphysiological systems: from organoid assembly to dynamic immune modelling.Frontiers in bioengineering and biotechnology · 2026Review
- Immune Microenvironment of Hair Follicles in Tumor Immunotherapy.ImmunoTargets and therapy · 2026Review
- Spatiotemporal decoding of skin biology: development, aging, disease, and regeneration.Burns & trauma · 2026Article
- Cold Atmospheric Plasma-Activated In Situ Hydrogel Induces Hair Regeneration Via Immune Microenvironment Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The resilient subset: cancer stem cells at the core of immunotherapy resistance.Immunotherapy advances · 2026Review
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Jarish N CohenDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6043-2177
Victoire GouirandDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2666-0061
Courtney E MaconDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6603-8907
Margaret M LoweDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5623-7707
Ian C BoothbyDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1112-2834
Joshua M MoreauDepartment of Cell, Developmental, and Cancer Biology, Oregon Health Sciences University, Portland, OR, USA.ORCID 0000-0002-1227-1508
Iris K GratzDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.ORCID 0000-0001-7470-7277
Angelika StoecklingerDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.ORCID 0000-0002-0351-8142
Casey T WeaverDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-2180-1793
Arlene H SharpeDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9736-2109
Roberto R Ricardo-GonzalezDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6135-4035
Michael D RosenblumDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0462-5732
University of California, San Francisco · USUniversity of Salzburg · ATBrigham and Women's Hospital · USOregon Health & Science University · USUniversity of Alabama at Birmingham · US
Funding
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MUCSF Dermatology Training GrantT32AR007175 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wilson Liao, Michael David Rosenblum · 1986 to 2026
$6.1MElucidating the Role of Regulatory T cells in Establishing and Maintaining a Th2 Niche in SkinR01AR077553 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2020 to 2024
$3.5MElucidating the Cellular and Molecular Mechanisms of How Regulatory T cells in Skin Regulate Fibroblast Activation and Tissue FibrosisR01AR071944 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2018 to 2022
$1.7MElucidating the role of type 2 immunity in skin homeostasisK08AR075880 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RICARDO-GONZALEZ, ROBERTO RAFAEL · 2019 to 2023
$888kElucidating the Role of Regulatory T cells in Protecting Epithelial Stem Cell NichesK08AR079596 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jarish Newman Cohen · 2022 to 2026
$882kBD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573kNIAID NIH HHS P01 AI056299NIAID NIH HHS T32 AI007334NIAMS NIH HHS K08 AR075880NIAMS NIH HHS K08 AR079596NIAMS NIH HHS R01 AR071944NIAMS NIH HHS R01 AR077553NIAMS NIH HHS T32 AR007175NIDDK NIH HHS P30 DK063720NIH HHS S10 OD021822
Abstract
Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in these tissues. We developed a technique to restrict genetic recombination to regulatory T cells (T
Indexed as
Immune PrivilegeT-Lymphocytes, RegulatoryHair FollicleHumansInterleukin-2Stem Cell NicheInterleukin-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.