Evidence map›Paper›PMID 38181094›Full record

ArticleScience immunology2024

A dynamic atlas of immunocyte migration from the gut.

Silvia Galván-Peña, Yangyang Zhu, Bola S Hanna, Diane Mathis, Christophe Benoist

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Gut Microbiota Dysbiosis MediatesImmunity, inflammation and disease · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. The gut-joint axis in juvenile idiopathic arthritis.Arthritis research & therapy · 2026
    Review
  17. Review
  18. Article
  19. Splenic PD-L1Research (Washington, D.C.) · 2026
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Silvia Galván-PeñaDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1639-2048
Yangyang ZhuDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Bola S HannaDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6110-4626
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1172-6555
Harvard University · US

Funding

Muscle Tregs in health and diseaseR01AR070334 · NIAMS · HARVARD MEDICAL SCHOOL · PI MATHIS, DIANE J · 2016 to 2025
$3.7M
T regulatory cell subsets at the microbial interface: determinism and functionR01AI125603 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2017 to 2021
$2.1M
NIAID NIH HHS R01 AI125603NIAMS NIH HHS R01 AR070334
6 · The paper itself

Abstract

Dysbiosis in the gut microbiota affects several systemic diseases, possibly by driving the migration of perturbed intestinal immunocytes to extraintestinal tissues. Combining Kaede photoconvertible mice and single-cell genomics, we generated a detailed map of migratory trajectories from the colon, at baseline, and in several models of intestinal and extraintestinal inflammation. All lineages emigrated from the colon in an S1P-dependent manner. B lymphocytes represented the largest contingent, with the unexpected circulation of nonexperienced follicular B cells, which carried a gut-imprinted transcriptomic signature. T cell emigration included distinct groups of RORγ

Indexed as

B-LymphocytesGastrointestinal MicrobiomeAnimalsDysbiosisGene Expression ProfilingInflammationMice

Identifiers

PMID38181094
PMCPMC10964343
OpenAlexW4390604086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.