ArticleSleep2024
The interrelationships between sleep regularity, obstructive sleep apnea, and hypertension in a middle-aged community population.
Article in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The relationship between vertigo severity, psychiatric symptoms and obstructive sleep apnoea.Journal of otology · 2026Article
- Zero burden multi night monitoring with AI enabled technology reduces obstructive sleep apnea misdiagnosis.NPJ digital medicine · 2026Article
- Health Related Quality of Life and Sleep Regularity Among Middle-Aged to Older Adults From the Community.Journal of sleep research · 2026Article
- The role of circadian disruption, sleep dysregulation, lifestyle factors, and metabolic reprogramming in the pathogenesis and progression of ovarian cancer.Journal of the National Cancer Center · 2026Review
- Association of bedtime with co-morbid hypertension in OSA: a community-based study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Weight and sleep health in OSA: exploring their link.Frontiers in sleep · 2026Article
- "Social Apnea": Obstructive Sleep Apnea Is Exacerbated on Weekends.American journal of respiratory and critical care medicine · 2025Article
- Validation study of the Arabic translation of the sleep regularity questionnaire (SRQ).Sleep & breathing = Schlaf & Atmung · 2025Article
- Article
- Sleep Irregularity, Circadian Disruption, and Cardiometabolic Disease Risk.Circulation research · 2025Review
- Obstructive sleep apnea severity varies by season and environmental influences such as ambient temperature.Communications medicine · 2025Article
- Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.Sleep medicine · 2025Article
- Association between sleep duration and hypertension risk in patients with obstructive sleep apnea.NPJ primary care respiratory medicine · 2025Article
- Association between sleep regularity and arterial stiffness among middle-age adults in Southwestern China.BMC public health · 2024Article
- The association between irregularity in sleep-wake rhythm and CPAP adherence.Npj biological timing and sleep · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
STUDY
objectivesLittle is known about the interrelationships between sleep regularity, obstructive sleep apnea (OSA) and important health markers. This study examined whether irregular sleep is associated with OSA and hypertension, and if this modifies the known association between OSA and hypertension.
methodsSix hundred and two adults (age mean(SD) = 56.96(5.51) years, female = 60%) from the Raine Study who were not evening or night shift workers were assessed for OSA (in-laboratory polysomnography; apnea-hypopnea index ≥ 15 events/hour), hypertension (doctor diagnosed, or systolic blood pressure ≥140 mmHg and/or diastolic ≥90 mmHg) and sleep (wrist actigraphy for ≥5 days). A sleep regularity index (SRI) was determined from actigraphy. Participants were categorized by tertiles as severely irregular, mildly irregular, or regular sleepers. Logistic regression models examined the interrelationships between SRI, OSA and hypertension. Covariates included age, sex, body mass index, actigraphy sleep duration, insomnia, depression, activity, alcohol, smoking, and antihypertensive medication.
resultsCompared to regular sleepers, participants with mildly irregular (OR 1.97, 95% confidence intervals [CI] 1.20 to 3.27) and severely irregular (OR 2.06, 95% CI: 1.25 to 3.42) sleep had greater odds of OSA. Compared to those with no OSA and regular sleep, OSA and severely irregular sleep combined had the highest odds of hypertension (OR 2.34 95% CI: 1.07 to 5.12; p for interaction = 0.02) while those with OSA and regular/mildly irregular sleep were not at increased risk (p for interaction = 0.20).
conclusionsSleep irregularity may be an important modifiable target for hypertension among those with OSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.