Evidence map›Paper›PMID 38180833›Full record

ArticleSTAR protocols2024

Protocol for transplanting pancreatic islets into the parametrial fat pad of female mice.

Mebrahtu G Tedla, Nathaniel Wright, Esma S Yolcu, Yadong Wang, Haval Shirwan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mebrahtu G TedlaDepartment of Pediatrics, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65211, USA; Department of Molecular Microbiology and Immunology, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65211, USA; NextGen Precision Health Institute, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65211, USA.
Nathaniel WrightMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.
Esma S YolcuDepartment of Pediatrics, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65211, USA; Department of Molecular Microbiology and Immunology, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65211, USA; NextGen Precision Health Institute, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65211, USA.
Yadong WangMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.
Haval ShirwanDepartment of Pediatrics, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65211, USA. Electronic address: haval.shirwan@health.missouri.edu.
Cancer Research Center · USCornell University · USUniversity of Missouri Health System · US

Funding

A novel immunomodulatory approach to overcome innate and adaptiveimmune barriers to islet transplantationR01AI121281 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI SHIRWAN, HAVAL · 2019 to 2024
$1.9M
NIAID NIH HHS R01 AI121281
6 · The paper itself

Abstract

Although the male epididymal fat pad is an effective site for islet transplantation, females lack this tissue. Here, we present a protocol to assess the parametrial fat pad (PFP) adjacent to the uterine horn in females as an alternative site for islet transplantation. We describe steps for islet isolation from the pancreas, counting, transplantation into PFP, and monitoring for engraftment. Transplantation into PFP is minimally invasive, time efficient, and supports long-term engraftment of syngeneic islets and rejection of allogeneic islets. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2022).

Indexed as

Diabetes Mellitus, ExperimentalIslets of LangerhansIslets of Langerhans TransplantationTransplantsAdipose TissueAnimalsFemaleMaleMiceCell isolationHealth SciencesImmunologyMetabolismModel Organisms

Identifiers

PMID38180833
PMCPMC10801339
OpenAlexW4390597610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.