Evidence map›Paper›PMID 38180461›Full record

ArticleMicrobiology (Reading, England)2024

An assessment of the airborne longevity of group A Streptococcus.

Henry P Oswin, Evie Blake, Allen E Haddrell, Adam Finn, Shiranee Sriskandan, Jonathan P Reid, Alice Halliday, Anu Goenka

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Microbiology (Reading, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Henry P OswinSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
Evie BlakeSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Allen E HaddrellSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
Adam FinnSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Shiranee SriskandanNIHR Health Protection Research Unit in Healthcare-associated Infection and Antimicrobial Resistance, Imperial College London, London, UK.
Jonathan P ReidSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
Alice HallidaySchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Anu GoenkaSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
University of Bristol · GBBristol Royal Hospital for Children · GBNIHR Imperial Biomedical Research Centre · GB

Funding

Medical Research Council MR/X001962/1Wellcome Trust
6 · The paper itself

Abstract

Group A streptococcus (GAS) infections result in more than 500 000 deaths annually. Despite mounting evidence for airborne transmission of GAS, little is known about its stability in aerosol. Measurements of GAS airborne stability were carried out using the Controlled Electrodynamic Levitation and Extraction of Bioaerosols onto a Substrate (CELEBS) instrument. CELEBS measurements with two different isolates of GAS suggest that it is aerostable, with approximately 70 % of bacteria remaining viable after 20 min of levitation at 50 % relative humidity (RH), with lower survival as RH was reduced. GAS airborne viability loss was driven primarily by desiccation and efflorescence (i.e. salt crystallization), with high pH also potentially playing a role, given reduced survival in bicarbonate containing droplet compositions. At low enough RH for efflorescence to occur, a greater proportion of organic components in the droplet appeared to protect the bacteria from efflorescence. These first insights into the aerosol stability of GAS indicate that airborne transmission of these respiratory tract bacteria may occur, and that both the composition of the droplet containing the bacteria, and the RH of the air affect the duration of bacterial survival in this environment. Future studies will explore a broader range of droplet and air compositions and include a larger selection of GAS strains.

Indexed as

Sodium ChlorideStreptococcus pyogenesAerosolsAerosolsSodium Chlorideaerosolairbornedropletgroup A streptococcustransmission

Identifiers

PMID38180461
PMCPMC10866022
OpenAlexW4390618470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.