Evidence map›Paper›PMID 38180340›Full record

ArticleeLife2024

Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery.

Jiyun Chen, Hong Chen, Shanshan Li, Xiaofeng Lin, Rong Hu, Kaiming Zhang, Liang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. RiboScreenBiomedicines · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiyun Chen *State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
Hong Chen *State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-0179-4493
Shanshan Li *MOE Key Laboratory for Cellular Dynamics and Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xiaofeng LinState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
Rong HuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
Kaiming ZhangMOE Key Laboratory for Cellular Dynamics and Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Liang LiuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-5379-0638
University of Science and Technology of China · CN

Funding

Center for Advanced Interdisciplinary Science and Biomedicine of IHM QYPY20220019National Natural Science Foundation of China 32022047National Natural Science Foundation of China 32171286The Fundamental Research Funds for the Central Universities WK9100000032The Fundamental Research Funds for the Central Universities WK9100000044The Ministry of Science and Technology of China 2022YFA1302700The Ministry of Science and Technology of China 2022YFC2303700The Strategic Priority Research Program of the Chinese Academy of Sciences XDB0490000
6 · The paper itself

Abstract

Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase responsible for rRNA maturation. Here, we report the structures of full-length

Indexed as

RNA PrecursorsRNA, RibosomalEndonucleasesRibosomesRNA Processing, Post-TranscriptionalEndonucleasesRNA PrecursorsRNA, RibosomalHEPN nucleasemolecular biophysicsPre-rRNA processingribosome biosynthesisS. cerevisiaestructural biology

Identifiers

PMID38180340
PMCPMC10942766
OpenAlexW4367680527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.